Cell Plasticity in Metastatic Colorectal Cancer

Project Information

PLASTICAN

Grant agreement ID: 101021078

DOI 10.3030/101021078

EC signature date 6 December 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG
Germany

Publications

Peer reviewed articles (7)

Image-guided radiotherapy in an orthotopic mouse model of rectal cancer

Author(s): Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2022.101749

Colon tumor cell death causes mTOR dependence by pararcrine P2X4 stimulation

Author(s): Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas A, Kennel KB, Engel E, Dabiri Y, Schewe M, Kirisozu A, Petrocelli V, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-022-05426-1

Expansion of T memory stem cells with superior antitumor immunity by Urolithin Ainduced mitophagy,

Author(s): Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs, K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux P, Rinsch C, Greten FR
Published in: Immunity, 2022, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.09.014

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Author(s): Kennel KB, Bozlar M, De Valk AF, Greten FR.
Published in: Clinical Cancer Research, 2022, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1031

Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses

Author(s): Henner F. Farin, Mohammed H. Mosa, Benardina Ndreshkjana, Britta M. Grebbin, Birgit Ritter, Constantin Menche, Kilian B. Kennel, Paul K. Ziegler, Lili Szabo, Julia Bollrath, Dietmar Rieder, Birgitta E. Michels, Alena Kress, Muge Bozlar, Tahmineh Darvishi, Sara Stier, Ivan-Maximiliano Kur, Katrin Bankov, Rebecca Kesselring, Stefan Fichtner-Feigl, Bernhard Brune, Thorsten O. Goetze, Salah-Eddin Al-
Published in: Cancer Discovery, 2023, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0050

Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Author(s): Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR.
Published in: Gastroenterology, 2022, ISSN 2771-0599
Publisher: Elsevier
DOI: 10.1053/j.gastro.2022.10.036

"""Combining ferroptosis induction with MDSC blockaderenders primary tumours and metastases in liversensitive to immune checkpoint blockade"""

Author(s): Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Greten FR
Published in: GUT, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327909