Cell Plasticity in Metastatic Colorectal Cancer

Project Information

PLASTICAN

Grant agreement ID: 101021078

DOI

10.3030/101021078

EC signature date 6 December 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Image-guided radiotherapy in an orthotopic mouse model of rectal cancer

Author(s): Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2022.101749

Aberrant alternative splicing of purinergic receptor <scp>P2RX4</scp> prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

Author(s): Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten
Published in: The Journal of Pathology, Issue 270, 2026, Page(s) 55-68, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.70082

Colon tumor cell death causes mTOR dependence by pararcrine P2X4 stimulation

Author(s): Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas A, Kennel KB, Engel E, Dabiri Y, Schewe M, Kirisozu A, Petrocelli V, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR.
Published in: Nature, 2022, ISSN 1476-4687
Publisher: Springer
DOI: 10.1038/s41586-022-05426-1

Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation

Author(s): Christopher Dietz-Fricke, Florian R. Greten
Published in: Signal Transduction and Targeted Therapy, Issue 10, 2025, ISSN 2059-3635
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41392-025-02244-5

Expansion of T memory stem cells with superior antitumor immunity by Urolithin Ainduced mitophagy,

Author(s): Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs, K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux P, Rinsch C, Greten FR
Published in: Immunity, 2022, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.09.014

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Author(s): Kennel KB, Bozlar M, De Valk AF, Greten FR.
Published in: Clinical Cancer Research, 2022, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1031

Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses

Author(s): Henner F. Farin, Mohammed H. Mosa, Benardina Ndreshkjana, Britta M. Grebbin, Birgit Ritter, Constantin Menche, Kilian B. Kennel, Paul K. Ziegler, Lili Szabo, Julia Bollrath, Dietmar Rieder, Birgitta E. Michels, Alena Kress, Muge Bozlar, Tahmineh Darvishi, Sara Stier, Ivan-Maximiliano Kur, Katrin Bankov, Rebecca Kesselring, Stefan Fichtner-Feigl, Bernhard Brune, Thorsten O. Goetze, Salah-Eddin Al-
Published in: Cancer Discovery, 2023, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0050

Gut microbial carcinogen metabolism: another avenue to cancer

Author(s): Florian R. Greten, Melek C. Arkan
Published in: Signal Transduction and Targeted Therapy, Issue 9, 2024, Page(s) 297, ISSN 2059-3635
Publisher: NPG
DOI: 10.1038/s41392-024-02015-8

Current and emerging concepts for systemic treatment of metastatic colorectal cancer

Author(s): Christoph Steup, Kilian B Kennel, Markus F Neurath, Stefan Fichtner-Feigl, Florian R Greten
Published in: Gut, Issue 74, 2025, Page(s) 2070-2095, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2025-335412

The immune microenvironment of colorectal cancer

Author(s): Kilian B. Kennel, Florian R. Greten
Published in: Nature Reviews Cancer, Issue 25, 2025, Page(s) 945-964, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-025-00872-1

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

Author(s): Dominic Denk, Mallika Ramakrishnan, Claire Conche, Charles Pallangyo, Marina Pesic, Fatih Ceteci, Kilian B. Kennel, Asude C. Kirisözü, Esther Engel, Kathleen Mohs, Birgit Ritter, Angeles Macias Pardo, Ezgi Özkurt, Falk Hildebrand, Ari Waisman, Melek C. Arkan, Florian R. Greten
Published in: Immunity, Issue 58, 2025, Page(s) 701-715.e8, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2025.02.005

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Author(s): Dominic Denk, Anurag Singh, Herbert G. Kasler, Davide D’Amico, Julia Rey, Lucía Alcober-Boquet, Johanna M. Gorol, Christoph Steup, Ritesh Tiwari, Ryan Kwok, Rafael J. Argüello, Julie Faitg, Kathrin Sprinzl, Stefan Zeuzem, Valentina Nekljudova, Sibylle Loibl, Eric Verdin, Chris Rinsch, Florian R. Greten
Published in: Nature Aging, Issue 5, 2026, Page(s) 2309-2322, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43587-025-00996-x

Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Author(s): Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR.
Published in: Gastroenterology, 2022, ISSN 2771-0599
Publisher: Elsevier
DOI: 10.1053/j.gastro.2022.10.036

"""Combining ferroptosis induction with MDSC blockaderenders primary tumours and metastases in liversensitive to immune checkpoint blockade"""

Author(s): Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Greten FR
Published in: GUT, 2023, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327909