Cell Plasticity in Metastatic Colorectal Cancer

Informazioni relative al progetto

PLASTICAN

ID dell’accordo di sovvenzione: 101021078

DOI 10.3030/101021078

Data della firma CE 6 Dicembre 2021

Data di avvio 1 Gennaio 2022

Data di completamento 31 Dicembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 500 000,00

Contributo UE € 2 500 000,00

Coordinato da

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG
Germany

Pubblicazioni

Peer reviewed articles (7)

Image-guided radiotherapy in an orthotopic mouse model of rectal cancer

Autori: Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR
Pubblicato in: STAR Protocols, 2022, ISSN 2666-1667
Editore: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2022.101749

Colon tumor cell death causes mTOR dependence by pararcrine P2X4 stimulation

Autori: Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas A, Kennel KB, Engel E, Dabiri Y, Schewe M, Kirisozu A, Petrocelli V, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR.
Pubblicato in: Nature, 2022, ISSN 1476-4687
Editore: Springer
DOI: 10.1038/s41586-022-05426-1

Expansion of T memory stem cells with superior antitumor immunity by Urolithin Ainduced mitophagy,

Autori: Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs, K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux P, Rinsch C, Greten FR
Pubblicato in: Immunity, 2022, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2022.09.014

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Autori: Kennel KB, Bozlar M, De Valk AF, Greten FR.
Pubblicato in: Clinical Cancer Research, 2022, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1031

Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses

Autori: Henner F. Farin, Mohammed H. Mosa, Benardina Ndreshkjana, Britta M. Grebbin, Birgit Ritter, Constantin Menche, Kilian B. Kennel, Paul K. Ziegler, Lili Szabo, Julia Bollrath, Dietmar Rieder, Birgitta E. Michels, Alena Kress, Muge Bozlar, Tahmineh Darvishi, Sara Stier, Ivan-Maximiliano Kur, Katrin Bankov, Rebecca Kesselring, Stefan Fichtner-Feigl, Bernhard Brune, Thorsten O. Goetze, Salah-Eddin Al-
Pubblicato in: Cancer Discovery, 2023, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0050

Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression

Autori: Boonsanay V, Mosa MH, Looso M, Weichenhan D, Ceteci F, Pudelko L, Lechel A, Michel CS, Künne C, Farin HF, Plass C, Greten FR.
Pubblicato in: Gastroenterology, 2022, ISSN 2771-0599
Editore: Elsevier
DOI: 10.1053/j.gastro.2022.10.036

"""Combining ferroptosis induction with MDSC blockaderenders primary tumours and metastases in liversensitive to immune checkpoint blockade"""

Autori: Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Greten FR
Pubblicato in: GUT, 2023, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2022-327909