Project description
Innovative model to study lung respiratory dynamics
The EU-funded BREATHE project aims to develop the first comprehensive computational model of the respiratory system, based on recent advances in high-performance simulation. The strategy will build on a recent model of an exascale-ready incompressible flow solver which will be modified for lung-specific challenges and will include capabilities to capture tissue interaction and gas transport. The respiratory zone will be represented by multiphase poroelastic media with specific pleural boundaries, and coupled pulmonary circulation will be represented by an embedded reduced dimensional network and additional phases. Individualisation of the model and adaptation to the conditions of disease progression will be achieved using a novel probabilistic learning approach. The developed model system will provide insights into the dynamic processes in human lungs for biomedical scientists and practitioners.
Fields of science
- medical and health sciencesclinical medicinepneumology
- medical and health sciencesmedical biotechnology
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- natural sciencesbiological sciencesbiophysics
- natural sciencescomputer and information sciencescomputational sciencemultiphysics
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced GrantHost institution
80333 Muenchen
Germany
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Beneficiaries (1)
80333 Muenchen
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