Conception by artificial reproductive technologies and offspring health

Información del proyecto

ART-HEALTH

Identificador del acuerdo de subvención: 101021566

DOI

10.3030/101021566

Fecha de la firma de la CE 19 Noviembre 2021

Fecha de inicio 1 Diciembre 2021

Fecha de finalización 30 Noviembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 951,00

Aportación de la UE

€ 2 499 951,00

Coordinado por

UNIVERSITY OF BRISTOL
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (28)

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Autores: Ahmed Elhakeem; Justiina Ronkainen; Toby Mansell; Katherine Lange; Tuija Mikkola; Binisha H Mishra; Rama Wahab; Tim Cadman; Tiffany Yang; David Burgner; Johan G Eriksson; Marjo-Riitta Järvelin; Romy Gaillard; Vincent WV Jaddoe; Terho Lehtimäki; Olli T Raitakari; Richard Saffery; Melissa Wake; John Wright; Sylvain Sebert; Deborah A Lawlor
Publicado en: VOLUME=21;ISSUE=1;ISSN=1741-7015;TITLE=BMC Medicine, Edición 7, 2023, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-022-02711-8

The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example

Autores: Kjersti Westvik-Johari; Siri E Håberg; Deborah A Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A Henningsen; Aila Tiitinen; Anja Pinborg; Signe Opdahl
Publicado en: International Journal of Epidemiology, Edición 3, 2023, ISSN 0300-5771
Editor: Oxford University Press
DOI: 10.1093/ije/dyad003

Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis

Autores: Ishikuro M, Nishimura T, Iwata H, et al.
Publicado en: Journal of human hypertension, 2024, ISSN 0950-9240
Editor: Nature Publishing Group
DOI: 10.1038/s41371-023-00890-2

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight

Autores: Ciarrah-Jane Shannon Barry; Deborah A. Lawlor; Chin Yang Shapland; Eleanor Sanderson; Maria Carolina Borges
Publicado en: Metabolites, Edición 1, 2022, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo12060537

Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies

Autores: Magnus MC, Fraser A, Håberg, SC, Rönö, C Romundstad LV, Bergh C, Spangmose AL, Pinborg A, Gissler M, Wennerholm U-B, Åsvold B, Lawlor DA, OpdahlS
Publicado en: JAMA Cardiology, 2023, ISSN 2380-6583
Editor: Online
DOI: 10.1001/jamacardio.2023.2324

Cohort profile: The Bristol IVF Study- A longitudinal study of women, their partners and treatment outcomes following assisted reproductive technologies

Autores: Amy E. Taylor, Taemi Kawahara, Jennifer Provis, Karema Al Rashid, Sophie Fitzgibbon, Alix Groom, Amanda Jefferys, Paul Wilson, Scott M Nelson, Valentine Akande, Deborah A Lawlor
Publicado en: PLoS One, Edición 21, 2026, Página(s) e0338907, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1101/2025.04.24.25326332

Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study

Autores: Skåra KH, Åsvold BO, Hernáez Á, Fraser A, Rich-Edwards JW, Farland LV, Næss Ø, Lawlor DA, Brumpton B, Magnus MC
Publicado en: Fertility and Sterility, 2022, ISSN 0015-0282
Editor: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.05.038

Evaluation and comparison of nine growth- and development-based measures of pubertal timing

Autores: Ahmed Elhakeem, Monika Frysz, Ana G Soares, Joshua A Bell, Tim J Cole, Jon Heron, Laura D Howe, Sylvain Sebert, Kate Tilling, Nicholas J Timpson, Deborah A Lawlor
Publicado en: Communications Medicine, Edición 4, 2026, Página(s) 159, ISSN 2730-664X
Editor: Nature Portfolio
DOI: 10.1101/2023.06.12.23290796

Risk of endometriosis, adenomyosis, and related symptoms among female offspring according to conception by assisted reproductive technologies

Autores: Maria C. Magnus, Dena Treider Alavi, Sunniva Nydal, Abigail Fraser, Deborah A. Lawlor, Kim Christian Danielsson, Siri E. Håberg, Hans Ivar Hanevik
Publicado en: Fertility and Sterility, Edición 125, 2026, Página(s) 608-616, ISSN 0015-0282
Editor: Elsevier BV
DOI: 10.1016/j.fertnstert.2025.10.002

Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses

Autores: Jie V Zhao, Ana Goncalves Soares, Demetris Avraam, Tim Cadman, Marie Aline Charles, Barbara Heude, Vincent Jaddoe, Yannis Manios, George Moschonis, Anne-Marie Nybo Andersen, Lorenzo Richiardi, Justiina Ronkainen, Sylvain Sebert, Morris Swertz, Evangelia Tzorovili, Martine Vrijheid, Wen Lun Yuan, Deborah A Lawlor, Ahmed Elhakeem
Publicado en: Exposome, Edición 5, 2025, ISSN 2635-2265
Editor: Oxford University Press (OUP)
DOI: 10.1093/exposome/osaf004

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Autores: Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Huang, Muriel Tafflet, Johan L. Vinther, Federica Asta, Jan S. Erkamp, Luigi Gagliardi, Kathrin Guerlich, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Toby Mansell, Fergus P. McCarthy, Sheila W. McDonald, Emanuela Medda, Lorenza Nisticò, Angela Pinot de Mo
Publicado en: Obstetrics and Gynecology, 2022, ISSN 0002-9378
Editor: Mosby Inc.
DOI: 10.1001/jamanetworkopen.2022.22106

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autores: Álvaro Hernáez; Karoline H. Skåra; Christian M. Page; Vera R. Mitter; Marta H. Hernández; Per Magnus; Pål R. Njølstad; Ole A. Andreassen; Elizabeth C. Corfield; Alexandra Havdahl; Øyvind Næss; Ben Brumpton; Bjørn Olav Åsvold; Deborah A. Lawlor; Abigail Fraser; Maria Christine Magnus
Publicado en: BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024), Edición 6, 2024, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Parental infertility and offspring cardiometabolic trajectories: a pooled analysis of three European cohorts

Autores: Hernáez A, Elhakeem A, Barros H, et al
Publicado en: Fertility and Sterility, 2024, ISSN 0015-0282
Editor: Elsevier BV
DOI: 10.1016/j.fertnstert.2024.01.017

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Autores: Ana Gonçalves Soares; Susana Santos; Emie Seyve; Rozenn Nedelec; Soile Puhakka; Aino-Maija Eloranta; Santtu Mikkonen; Wen Lun Yuan; Deborah A Lawlor; Jon Heron; Martine Vrijheid; Johanna Lepeule; Mark Nieuwenhuijsen; Serena Fossati; Vincent W V Jaddoe; Timo Lakka; Sylvain Sebert; Barbara Heude; Janine F Felix; Ahmed Elhakeem; Nicholas J Timpson
Publicado en: Soares , A G , Santos , S , Seyve , E , Nedelec , R , Puhakka , S , Eloranta , A-M , Mikkonen , S , Yuan , W L , Lawlor , D A , Heron , J , Vrijheid , M , Lepeule , J , Nieuwenhuijsen , M , Fossati , S , Jaddoe , V W V , Lakka , T , Sebert , S , Heude , B , Felix , J F , Elhakeem , A & Timpson , N J 2023 ' Prenatal urban environment and blood pressure trajectories from childhood to early adulthood, Edición 11, 2024, ISSN 2772-963X
Editor: online
DOI: 10.1016/j.jacadv.2023.100808

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Autores: Ahmed Elhakeem; Amy E Taylor; Hazel M Inskip; Jonathan Y Huang; Toby Mansell; Carina Rodrigues; Federica Asta; Sophia M Blaauwendraad; Siri E Håberg; Jane Halliday; Margreet W Harskamp-van Ginkel; Jian-Rong He; Vincent W V Jaddoe; Sharon Lewis; Gillian M Maher; Yannis Manios; Fergus P McCarthy; Irwin K M Reiss; Franca Rusconi; Theodosia Salika; Muriel Tafflet; Xiu Qiu; Bjørn O Åsvold; David Bur
Publicado en: 1-11, Edición 4, 2023, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehac726

General health in a cohort of children conceived after assisted reproductive technology in the United Kingdom: a population-based record-linkage study

Autores: Alastair G.Sutcliffe, Mitana Purkayastha, Daniel R.Brison, Scott M.Nelson, Stephen A.Roberts, Deborah A.Lawlor
Publicado en: American Journal of Obstetrics & Gynecology, 2022, ISSN 0002-9378
Editor: Mosby Inc.
DOI: 10.1016/j.ajog.2022.07.032

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort Study

Autores: Álvaro Hernáez; Yunsung Lee; Christian M Page; Karoline H Skåra; Siri E Håberg; Per Magnus; Pål R Njølstad; Ole A Andreassen; Elizabeth C Corfield; Alexandra Havdahl; Abigail Fraser; Stephen Burgess; Deborah A Lawlor; Maria C Magnus
Publicado en: Human Reproduction, Edición 4, 2024, ISSN 1460-2350
Editor: Online
DOI: 10.1101/2023.01.26.23285048

Preterm birth in assisted reproduction: the mediating role of hypertensive disorders in pregnancy

Autores: Sindre Hoff Petersen, Bjørn Olav Åsvold, Deborah A Lawlor, Anja Pinborg, Anne Lærke Spangmose, Liv Bente Romundstad, Christina Bergh, Ulla-Britt Wennerholm, Mika Gissler, Aila Tiitinen, Ahmed Elhakeem, Signe Opdahl
Publicado en: Human Reproduction, Edición 40, 2025, Página(s) 167-177, ISSN 0268-1161
Editor: Oxford University Press
DOI: 10.1093/humrep/deae261

Perinatal health in a cohort of children conceived after assisted reproduction in the UK: a population-based record-linkage study

Autores: Mitana Purkayastha, Alastair Sutcliffe, Daniel R Brison, Scott M Nelson, Deborah Lawlor, Stephen A Roberts
Publicado en: BMJ Open, Edición 14, 2025, Página(s) e091910, ISSN 2044-6055
Editor: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-091910

Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial

Autores: Anna M. Dieberger, Mireille N. M. van Poppel, Gernot Desoye, David Simmons, Jürgen Harreiter, Roland Devlieger, Carmen Medina, Deborah A. Lawlor, Ahmed Elhakeem, on behalf of the DALI core investigator group.
Publicado en: Pediatric Obesity, Edición 5, 2025, Página(s) e13199, ISSN 2047-6310
Editor: Wiley-Blackwell for the International Association for the Study of Obesity

Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study

Autores: Ahmed Elhakeem, Gemma L. Clayton, Ana Goncalves Soares, Kurt Taylor, Léa Maitre, Gillian Santorelli, John Wright, Deborah A. Lawlor, Martine Vrijheid
Publicado en: BMC Pregnancy and Childbirth, Edición 24, 2024, Página(s) 333, ISSN 1471-2393
Editor: BioMed Central
DOI: 10.1186/s12884-024-06538-4

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Autores: Samvida S. Venkatesh, Laura B. L. Wittemans, Duncan S. Palmer, Nikolas A. Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J. Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie T. Bruun, Christian Erikstrup, Bitten Aagard Jensen, Anders Juul, Christina Mikkelsen, Henriette S. Nielsen, Sisse R. Ostrowski, Ole B. Pedersen, Palle Duun Rohde, Erik Sørensen, Henrik Ullum, Dav
Publicado en: Nature Genetics, Edición 57, 2025, Página(s) 1107-1118, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-025-02156-8

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Autores: Kjersti Westvik-Johari; Deborah A. Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A. Henningsen; Siri E. Håberg; Aila Tiitinen; Anne Lærke Spangmose; Anja Pinborg; Signe Opdahl
Publicado en: Fertility and Sterility, Edición 2, 2023, ISSN 0015-0282
Editor: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.10.020

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Autores: Robyn E. Wootton; Rebecca B. Lawn; Maria C. Magnus; Jorien L. Treur; Elizabeth C. Corfield; Pål R. Njølstad; Ole A. Andreassen; Deborah A. Lawlor; Marcus R. Munafò; Siri E. Håberg; George Davey Smith; Ted Reichborn-Kjennerud; Per Magnus; Alexandra Havdahl
Publicado en: 1-17, Edición 7, 2023, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-023-02831-9

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study

Autores: Karoline H Skåra, Álvaro Hernáez, Øyvind Næss, Abigail Fraser, Deborah A Lawlor, Stephen Burgess, Ben M Brumpton, Maria C Magnus
Publicado en: Human Reproduction Open, Edición 2024, 2024, Página(s) hoae033, ISSN 2399-3529
Editor: Oxford University Press (OUP)
DOI: 10.1093/hropen/hoae033

Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health

Autores: Alesha A Hatton, Caroline Brito Nunes, Deborah A Lawlor, David M Evans
Publicado en: International Journal of Epidemiology, Edición 55, 2026, ISSN 0300-5771
Editor: Oxford University Press
DOI: 10.1093/ije/dyag030

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Autores: Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington
Publicado en: Nature Communications, Edición 15, 2024, Página(s) 10067, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53687-3

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Autores: Robin N. Beaumont, Christopher Flatley, Marc Vaudel, Xiaoping Wu, Jing Chen, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Solé-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, João Fadista, Sara Elizabeth Stinson, Katerina Trajanoska, Carol A. Wang, David Westergaard, Sundararajan Srinivasan, Carlos Sánchez-Soriano, Jose Ramon Bilbao, Catherine Allard, Marika Groleau, Teemu
Publicado en: Nature Genetics, Edición 55, 2023, Página(s) 1807-1819, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01520-w