Conception by artificial reproductive technologies and offspring health

Informacje na temat projektu

ART-HEALTH

Identyfikator umowy o grant: 101021566

DOI

10.3030/101021566

Data podpisania przez KE 19 Listopada 2021

Data rozpoczęcia 1 Grudnia 2021

Data zakończenia 30 Listopada 2026

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 499 951,00

Wkład UE

€ 2 499 951,00

Koordynowany przez

UNIVERSITY OF BRISTOL
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (28)

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Autorzy: Ahmed Elhakeem; Justiina Ronkainen; Toby Mansell; Katherine Lange; Tuija Mikkola; Binisha H Mishra; Rama Wahab; Tim Cadman; Tiffany Yang; David Burgner; Johan G Eriksson; Marjo-Riitta Järvelin; Romy Gaillard; Vincent WV Jaddoe; Terho Lehtimäki; Olli T Raitakari; Richard Saffery; Melissa Wake; John Wright; Sylvain Sebert; Deborah A Lawlor
Opublikowane w: VOLUME=21;ISSUE=1;ISSN=1741-7015;TITLE=BMC Medicine, Numer 7, 2023, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-022-02711-8

The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example

Autorzy: Kjersti Westvik-Johari; Siri E Håberg; Deborah A Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A Henningsen; Aila Tiitinen; Anja Pinborg; Signe Opdahl
Opublikowane w: International Journal of Epidemiology, Numer 3, 2023, ISSN 0300-5771
Wydawca: Oxford University Press
DOI: 10.1093/ije/dyad003

Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis

Autorzy: Ishikuro M, Nishimura T, Iwata H, et al.
Opublikowane w: Journal of human hypertension, 2024, ISSN 0950-9240
Wydawca: Nature Publishing Group
DOI: 10.1038/s41371-023-00890-2

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight

Autorzy: Ciarrah-Jane Shannon Barry; Deborah A. Lawlor; Chin Yang Shapland; Eleanor Sanderson; Maria Carolina Borges
Opublikowane w: Metabolites, Numer 1, 2022, ISSN 2218-1989
Wydawca: MDPI
DOI: 10.3390/metabo12060537

Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies

Autorzy: Magnus MC, Fraser A, Håberg, SC, Rönö, C Romundstad LV, Bergh C, Spangmose AL, Pinborg A, Gissler M, Wennerholm U-B, Åsvold B, Lawlor DA, OpdahlS
Opublikowane w: JAMA Cardiology, 2023, ISSN 2380-6583
Wydawca: Online
DOI: 10.1001/jamacardio.2023.2324

Cohort profile: The Bristol IVF Study- A longitudinal study of women, their partners and treatment outcomes following assisted reproductive technologies

Autorzy: Amy E. Taylor, Taemi Kawahara, Jennifer Provis, Karema Al Rashid, Sophie Fitzgibbon, Alix Groom, Amanda Jefferys, Paul Wilson, Scott M Nelson, Valentine Akande, Deborah A Lawlor
Opublikowane w: PLoS One, Numer 21, 2026, Strona(/y) e0338907, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1101/2025.04.24.25326332

Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study

Autorzy: Skåra KH, Åsvold BO, Hernáez Á, Fraser A, Rich-Edwards JW, Farland LV, Næss Ø, Lawlor DA, Brumpton B, Magnus MC
Opublikowane w: Fertility and Sterility, 2022, ISSN 0015-0282
Wydawca: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.05.038

Evaluation and comparison of nine growth- and development-based measures of pubertal timing

Autorzy: Ahmed Elhakeem, Monika Frysz, Ana G Soares, Joshua A Bell, Tim J Cole, Jon Heron, Laura D Howe, Sylvain Sebert, Kate Tilling, Nicholas J Timpson, Deborah A Lawlor
Opublikowane w: Communications Medicine, Numer 4, 2026, Strona(/y) 159, ISSN 2730-664X
Wydawca: Nature Portfolio
DOI: 10.1101/2023.06.12.23290796

Risk of endometriosis, adenomyosis, and related symptoms among female offspring according to conception by assisted reproductive technologies

Autorzy: Maria C. Magnus, Dena Treider Alavi, Sunniva Nydal, Abigail Fraser, Deborah A. Lawlor, Kim Christian Danielsson, Siri E. Håberg, Hans Ivar Hanevik
Opublikowane w: Fertility and Sterility, Numer 125, 2026, Strona(/y) 608-616, ISSN 0015-0282
Wydawca: Elsevier BV
DOI: 10.1016/j.fertnstert.2025.10.002

Determinants of body mass index during early life: findings from an exposome-wide association study with follow-up replication and Mendelian randomization analyses

Autorzy: Jie V Zhao, Ana Goncalves Soares, Demetris Avraam, Tim Cadman, Marie Aline Charles, Barbara Heude, Vincent Jaddoe, Yannis Manios, George Moschonis, Anne-Marie Nybo Andersen, Lorenzo Richiardi, Justiina Ronkainen, Sylvain Sebert, Morris Swertz, Evangelia Tzorovili, Martine Vrijheid, Wen Lun Yuan, Deborah A Lawlor, Ahmed Elhakeem
Opublikowane w: Exposome, Numer 5, 2025, ISSN 2635-2265
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/exposome/osaf004

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Autorzy: Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Huang, Muriel Tafflet, Johan L. Vinther, Federica Asta, Jan S. Erkamp, Luigi Gagliardi, Kathrin Guerlich, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Toby Mansell, Fergus P. McCarthy, Sheila W. McDonald, Emanuela Medda, Lorenza Nisticò, Angela Pinot de Mo
Opublikowane w: Obstetrics and Gynecology, 2022, ISSN 0002-9378
Wydawca: Mosby Inc.
DOI: 10.1001/jamanetworkopen.2022.22106

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Autorzy: Álvaro Hernáez; Karoline H. Skåra; Christian M. Page; Vera R. Mitter; Marta H. Hernández; Per Magnus; Pål R. Njølstad; Ole A. Andreassen; Elizabeth C. Corfield; Alexandra Havdahl; Øyvind Næss; Ben Brumpton; Bjørn Olav Åsvold; Deborah A. Lawlor; Abigail Fraser; Maria Christine Magnus
Opublikowane w: BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024), Numer 6, 2024, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Parental infertility and offspring cardiometabolic trajectories: a pooled analysis of three European cohorts

Autorzy: Hernáez A, Elhakeem A, Barros H, et al
Opublikowane w: Fertility and Sterility, 2024, ISSN 0015-0282
Wydawca: Elsevier BV
DOI: 10.1016/j.fertnstert.2024.01.017

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Autorzy: Ana Gonçalves Soares; Susana Santos; Emie Seyve; Rozenn Nedelec; Soile Puhakka; Aino-Maija Eloranta; Santtu Mikkonen; Wen Lun Yuan; Deborah A Lawlor; Jon Heron; Martine Vrijheid; Johanna Lepeule; Mark Nieuwenhuijsen; Serena Fossati; Vincent W V Jaddoe; Timo Lakka; Sylvain Sebert; Barbara Heude; Janine F Felix; Ahmed Elhakeem; Nicholas J Timpson
Opublikowane w: Soares , A G , Santos , S , Seyve , E , Nedelec , R , Puhakka , S , Eloranta , A-M , Mikkonen , S , Yuan , W L , Lawlor , D A , Heron , J , Vrijheid , M , Lepeule , J , Nieuwenhuijsen , M , Fossati , S , Jaddoe , V W V , Lakka , T , Sebert , S , Heude , B , Felix , J F , Elhakeem , A & Timpson , N J 2023 ' Prenatal urban environment and blood pressure trajectories from childhood to early adulthood, Numer 11, 2024, ISSN 2772-963X
Wydawca: online
DOI: 10.1016/j.jacadv.2023.100808

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Autorzy: Ahmed Elhakeem; Amy E Taylor; Hazel M Inskip; Jonathan Y Huang; Toby Mansell; Carina Rodrigues; Federica Asta; Sophia M Blaauwendraad; Siri E Håberg; Jane Halliday; Margreet W Harskamp-van Ginkel; Jian-Rong He; Vincent W V Jaddoe; Sharon Lewis; Gillian M Maher; Yannis Manios; Fergus P McCarthy; Irwin K M Reiss; Franca Rusconi; Theodosia Salika; Muriel Tafflet; Xiu Qiu; Bjørn O Åsvold; David Bur
Opublikowane w: 1-11, Numer 4, 2023, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehac726

General health in a cohort of children conceived after assisted reproductive technology in the United Kingdom: a population-based record-linkage study

Autorzy: Alastair G.Sutcliffe, Mitana Purkayastha, Daniel R.Brison, Scott M.Nelson, Stephen A.Roberts, Deborah A.Lawlor
Opublikowane w: American Journal of Obstetrics & Gynecology, 2022, ISSN 0002-9378
Wydawca: Mosby Inc.
DOI: 10.1016/j.ajog.2022.07.032

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort Study

Autorzy: Álvaro Hernáez; Yunsung Lee; Christian M Page; Karoline H Skåra; Siri E Håberg; Per Magnus; Pål R Njølstad; Ole A Andreassen; Elizabeth C Corfield; Alexandra Havdahl; Abigail Fraser; Stephen Burgess; Deborah A Lawlor; Maria C Magnus
Opublikowane w: Human Reproduction, Numer 4, 2024, ISSN 1460-2350
Wydawca: Online
DOI: 10.1101/2023.01.26.23285048

Preterm birth in assisted reproduction: the mediating role of hypertensive disorders in pregnancy

Autorzy: Sindre Hoff Petersen, Bjørn Olav Åsvold, Deborah A Lawlor, Anja Pinborg, Anne Lærke Spangmose, Liv Bente Romundstad, Christina Bergh, Ulla-Britt Wennerholm, Mika Gissler, Aila Tiitinen, Ahmed Elhakeem, Signe Opdahl
Opublikowane w: Human Reproduction, Numer 40, 2025, Strona(/y) 167-177, ISSN 0268-1161
Wydawca: Oxford University Press
DOI: 10.1093/humrep/deae261

Perinatal health in a cohort of children conceived after assisted reproduction in the UK: a population-based record-linkage study

Autorzy: Mitana Purkayastha, Alastair Sutcliffe, Daniel R Brison, Scott M Nelson, Deborah Lawlor, Stephen A Roberts
Opublikowane w: BMJ Open, Numer 14, 2025, Strona(/y) e091910, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-091910

Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial

Autorzy: Anna M. Dieberger, Mireille N. M. van Poppel, Gernot Desoye, David Simmons, Jürgen Harreiter, Roland Devlieger, Carmen Medina, Deborah A. Lawlor, Ahmed Elhakeem, on behalf of the DALI core investigator group.
Opublikowane w: Pediatric Obesity, Numer 5, 2025, Strona(/y) e13199, ISSN 2047-6310
Wydawca: Wiley-Blackwell for the International Association for the Study of Obesity

Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study

Autorzy: Ahmed Elhakeem, Gemma L. Clayton, Ana Goncalves Soares, Kurt Taylor, Léa Maitre, Gillian Santorelli, John Wright, Deborah A. Lawlor, Martine Vrijheid
Opublikowane w: BMC Pregnancy and Childbirth, Numer 24, 2024, Strona(/y) 333, ISSN 1471-2393
Wydawca: BioMed Central
DOI: 10.1186/s12884-024-06538-4

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum

Autorzy: Samvida S. Venkatesh, Laura B. L. Wittemans, Duncan S. Palmer, Nikolas A. Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J. Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie T. Bruun, Christian Erikstrup, Bitten Aagard Jensen, Anders Juul, Christina Mikkelsen, Henriette S. Nielsen, Sisse R. Ostrowski, Ole B. Pedersen, Palle Duun Rohde, Erik Sørensen, Henrik Ullum, Dav
Opublikowane w: Nature Genetics, Numer 57, 2025, Strona(/y) 1107-1118, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-025-02156-8

Risk of stillbirth and neonatal death in singletons born after fresh and frozen embryo transfer: cohort study from the Committee of Nordic Assisted Reproduction Technology and Safety

Autorzy: Kjersti Westvik-Johari; Deborah A. Lawlor; Liv Bente Romundstad; Christina Bergh; Ulla-Britt Wennerholm; Mika Gissler; Anna-Karina A. Henningsen; Siri E. Håberg; Aila Tiitinen; Anne Lærke Spangmose; Anja Pinborg; Signe Opdahl
Opublikowane w: Fertility and Sterility, Numer 2, 2023, ISSN 0015-0282
Wydawca: Elsevier BV
DOI: 10.1016/j.fertnstert.2022.10.020

Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Autorzy: Robyn E. Wootton; Rebecca B. Lawn; Maria C. Magnus; Jorien L. Treur; Elizabeth C. Corfield; Pål R. Njølstad; Ole A. Andreassen; Deborah A. Lawlor; Marcus R. Munafò; Siri E. Håberg; George Davey Smith; Ted Reichborn-Kjennerud; Per Magnus; Alexandra Havdahl
Opublikowane w: 1-17, Numer 7, 2023, ISSN 1741-7015
Wydawca: BioMed Central
DOI: 10.1186/s12916-023-02831-9

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study

Autorzy: Karoline H Skåra, Álvaro Hernáez, Øyvind Næss, Abigail Fraser, Deborah A Lawlor, Stephen Burgess, Ben M Brumpton, Maria C Magnus
Opublikowane w: Human Reproduction Open, Numer 2024, 2024, Strona(/y) hoae033, ISSN 2399-3529
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/hropen/hoae033

Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health

Autorzy: Alesha A Hatton, Caroline Brito Nunes, Deborah A Lawlor, David M Evans
Opublikowane w: International Journal of Epidemiology, Numer 55, 2026, ISSN 0300-5771
Wydawca: Oxford University Press
DOI: 10.1093/ije/dyag030

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Autorzy: Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington
Opublikowane w: Nature Communications, Numer 15, 2024, Strona(/y) 10067, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-53687-3

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Autorzy: Robin N. Beaumont, Christopher Flatley, Marc Vaudel, Xiaoping Wu, Jing Chen, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Solé-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, João Fadista, Sara Elizabeth Stinson, Katerina Trajanoska, Carol A. Wang, David Westergaard, Sundararajan Srinivasan, Carlos Sánchez-Soriano, Jose Ramon Bilbao, Catherine Allard, Marika Groleau, Teemu
Opublikowane w: Nature Genetics, Numer 55, 2023, Strona(/y) 1807-1819, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-023-01520-w