PrediKSion: An evolutionary guided and experimentally validated computational pipeline to unravel new polyketide synthase functionality

Project Information

PrediKSion

Grant agreement ID: 101022873

DOI 10.3030/101022873

Project terminated on 31 October 2023

EC signature date 22 April 2021

Start date 1 January 2022

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 191 149,44

EU contribution € 191 149,44

Coordinated by

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

Publications

Peer reviewed articles (3)

Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis

Author(s): Amy E. Fraley, Cora L. Dieterich, Mathijs F. J. Mabesoone, Hannah A. Minas, Roy A Meoded, Franziska Hemmerling, Jörn Piel
Published in: Angewandte Chemie, International Edition, Issue 61, 2022, Page(s) e202206385, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206385

Evolution-guided engineering of trans-acyltransferase polyketide synthases

Author(s): Mabesoone, Mathijs F. J. Leopold-Messer, Stefan Minas, Hannah A. Chepkirui, Clara Chawengrum, Pornsuda Reiter, Silke Meoded, Roy A. Wolf, Sarah Genz, Ferdinand Magnus, Nancy Piechulla, Birgit Walker, Allison S. Piel, Jörn
Published in: Science, Issue 383, 2024, Page(s) 1312-1317, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adj7621

Animal-associated marine Acidobacteria with a rich natural-product repertoire

Author(s): Stefan Leopold-Messer, Clara Chepkirui, Mathijs F.J. Mabesoone, Joshua Meyer, Lucas Paoli, Shinichi Sunagawa, Agustinus R. Uria, Toshiyuki Wakimoto, Jörn Piel
Published in: Chem, Issue 9(12), 2023, Page(s) 3696-3713, ISSN 2451-9308
Publisher: Elsevier
DOI: 10.1016/j.chempr.2023.11.003