PrediKSion: An evolutionary guided and experimentally validated computational pipeline to unravel new polyketide synthase functionality

Project description

A sustainable way of producing novel antibiotics

Polyketides are a large class of secondary metabolites from bacteria, fungi and plants with interesting and valuable activities. They are exploited as antibiotics, antifungals and drugs and can be chemically synthesised or produced from biological sources. The EU-funded PrediKSion project proposes to exploit acyltransferase polyketide synthase (AT PKS) enzymes from bacteria as a sustainable way to produce polyketides. To unveil new biosynthetic features in AT PKS, researchers will develop a computational pipeline that will assess the functionality of uncharacterised enzymes. Long term this will lead to the discovery of novel pharmaceutical entities

Fields of science

• natural sciences › biological sciences › biological morphology › comparative morphology
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Net EU contribution

€ 191 149,44

Address

Raemistrasse 101
8092 Zuerich
Switzerland

Region

Schweiz/Suisse/Svizzera › Zürich › Zürich

Activity type

Higher or Secondary Education Establishments

Links

Non-EU contribution

€ 0,00