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PrediKSion: An evolutionary guided and experimentally validated computational pipeline to unravel new polyketide synthase functionality

Project description

A sustainable way of producing novel antibiotics

Polyketides are a large class of secondary metabolites from bacteria, fungi and plants with interesting and valuable activities. They are exploited as antibiotics, antifungals and drugs and can be chemically synthesised or produced from biological sources. The EU-funded PrediKSion project proposes to exploit acyltransferase polyketide synthase (AT PKS) enzymes from bacteria as a sustainable way to produce polyketides. To unveil new biosynthetic features in AT PKS, researchers will develop a computational pipeline that will assess the functionality of uncharacterised enzymes. Long term this will lead to the discovery of novel pharmaceutical entities

Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution
€ 191 149,44
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00