Project description
Mapping memory in the brain
Embedded deep into the temporal lobe, the hippocampus plays an important role in memory. It encodes ‘memory traces’ of our experiences and ‘replays’ them when we sleep. This is essential for memory consolidation. To shed light on how this works, the EU-funded FUS-REPLAY project will explore the whole-brain correlates of hippocampal replay. It will use functional ultrasound to monitor subtle changes in cerebral blood flow over the whole brain at a resolution of up to tens of milliseconds, in combination with high-density electrophysiology. The project will establish ‘brain maps’ associated with hippocampal replay and learn how to decode a specific memory trace from these maps. It will also study how emotional valence affects these maps.
Objective
How can we vividly remember so many episodes of our life that, by definition, only happened once? During wakefulness, the hippocampus – a brain structure critical for episodic memory – encodes ‘memory traces’ of our experience. During sleep, it “replays” the very same sequences of neurons that were originally activated during the awake episode. Such reactivations are essential for memory consolidation. Over the years, a growing body of studies have unveiled “on-site” reactivations within the hippocampus, sometimes with a neocortical or subcortical “partner” structure, but the overall activity in the brain during these events remains largely unknown. It is unclear whether brain regions replay memory traces all at once or separately. This is a major knowledge gap because numerous cortical and subcortical structures strongly influence memory. In this project, we propose a unique combination of recording and analysis techniques to reveal the whole-brain correlates of hippocampal replay. To achieve this, we will use functional ultrasound, a newly emerging technology which monitors subtle changes in cerebral blood flow over the whole brain at a resolution up to tens of milliseconds, in combination with high-density electrophysiology, the actual gold-standard to record neuronal activity. With the help of a dedicated behavioral task, we will first establish ‘brain maps’ associated with hippocampal replay and then learn how to decode a specific memory trace from these maps. In a second time, we will investigate how emotional valence affects these maps, and in particular how replay patterns are modified over the course of learning. This project has the potential to track across the brain an individual memory trace from its creation to storage, all along consolidation processes. This project will considerably enhance our understanding of memory networks and potentially provide new regions of interest for the study of neurodegenerative disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.