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Chemical mutagenesis: a powerful tool for the creation of a library of nanobodies

Project description

Improving nanobodies’ affinity via chemical mutagenesis

Cancer immunotherapy has emerged as one of the best alternatives to current chemotherapy treatments. Nanobodies (VHH antibodies) are antibodies with a single variable domain located on a heavy chain. Conventional antibodies have VH and VL variable domains, which provide stability and binding specificity. Nanobodies have VHH domains and lack VL domains and occur naturally in camelids and sharks. Nanobodies have found use in such medical fields as oncology, infection and immunity. The EU-funded Chemical Mutagenesis project proposes the development of nanobodies able to recognise HER-2 protein and PD-1 receptors in cancer cells. The objective is to improve the nanobodies’ affinity to their targets using chemical mutagenesis via alanyl radicals, with a goal of resolving the challenges of cancer resistance in the context of immunotherapy.

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 212 933,76
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00