Project description
How do cells decide how to repair their DNA?
Eukaryotic cells have evolved different mechanisms of responding to DNA damage and repairing DNA double-strand breaks. However, many details regarding these processes are incompletely understood. The EU-funded coDNAres project aims to shed light on how cells decide to proceed with non-homologous end-joining, which is prone to errors, or the high-fidelity homologous recombination approach. Researchers will employ Caenorhabditis elegans as a model system to elucidate how cohesins – traditionally known for keeping sister chromatids together – affect chromosome segregation and DNA repair. Results will help elucidate the role of cohesins in maintaining genomic stability.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF-EF-ST - Standard EFCoordinator
41004 Sevilla
Spain
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