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Regulation of DNA resection, DNA repair and genomic stability by cohesin in undifferentiated Caenorhabditis elegans germ cells

Project description

How do cells decide how to repair their DNA?

Eukaryotic cells have evolved different mechanisms of responding to DNA damage and repairing DNA double-strand breaks. However, many details regarding these processes are incompletely understood. The EU-funded coDNAres project aims to shed light on how cells decide to proceed with non-homologous end-joining, which is prone to errors, or the high-fidelity homologous recombination approach. Researchers will employ Caenorhabditis elegans as a model system to elucidate how cohesins – traditionally known for keeping sister chromatids together – affect chromosome segregation and DNA repair. Results will help elucidate the role of cohesins in maintaining genomic stability.

Coordinator

UNIVERSIDAD DE SEVILLA
Net EU contribution
€ 160 932,48
Address
Calle S. Fernando 4
41004 Sevilla
Spain

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Region
Andalucía Sevilla
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00