Project description
Paving the way for personalised medicine of paediatric mild traumatic brain injury
The human brain undergoes major changes in its structure and functioning during childhood and adolescence. At this age period, a mild traumatic brain injury (mTBI) hits the still-developing brain, and can result in significant long-term impairment in emotion, cognition, behaviour, and social functioning. The EU-funded project INITIATE considers the individuality of each child with mTBI to better understand the variability and complexity of the consequences of paediatric mTBI. Specifically, it will combine advanced neuroimaging techniques with an individualised and longitudinal approach to characterise the individual profile of injury and the changes in brain development following mTBI in children and adolescents. In doing so INITIATE will pave the way toward personalised medicine of paediatric mTBI.
Objective
Paediatric mild traumatic brain injury (pmTBI) is a very common brain disorder that affects the brain during important developmental changes. The transition between childhood and adolescence (8-16 years of age) is characterised by profound changes in the brain structure and functioning. At this age period, the injury hits the still-developing brain regions underlying emotion, cognition, behaviour, and socialisation, and can result in significant long-term impairment in these functional domains.
Each pmTBI is unique based on the individuality of brain injury (i.e. location and magnitude of injury) that is superimposed on the individuality of brain development (i.e. trajectory varies between children). However, the current “one size fits all” approach that consider all children with mTBI as a homogenous group, lacks the precision needed to capture these individualities. INITIATE proposes to combine, for the first-time, advanced neuroimaging techniques with an individualised and longitudinal approach to characterise the individual profile of injury and the changes in brain development following mTBI in children.
This innovative approach will allow to capture the individuality of each child with mTBI and thereby to better understand the variability and complexity of the consequences of pmTBI. INITIATE findings have the potential to open new directions in research of pmTBI, and to move the field to a more individualised approach, a first step toward personalised medicine of pmTBI in the long-term.
Furthermore, this fellowship will enable me to gain extensive knowledge in paediatric medicine, advanced neuroimaging and developmental neuroscience, thereby giving me the opportunity to develop into an independent researcher in the field of TBI and brain development and to lead my own research my own research group and to conduct high quality research at a European University.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences health sciences personalized medicine
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.