Innovative hydrogel as a carrier to aid in the fight against Pseudomonas aeruginosa biofilms
Pseudomonas aeruginosa (PA) is a common gram-negative aerobic bacterium with advanced multidrug resistance mechanisms. It causes disease in plants, animals and humans and is associated with deadly hospital-acquired infections. PA can form biofilms, which are structured bacterial communities a thousand times less sensitive to antibiotics. Funded by the Marie Skłodowska-Curie Actions programme, the MONAGEL project proposes to combat PA biofilms by developing a hydrogel made of cross-linked lipid nanoparticles with encapsulated hydrophobic and hydrophilic active ingredients. The applicability and efficacy of the approach will be assessed in various cell lines and demonstrated on a co-culture epithelium/biofilm model as a proof of concept for further development.
Fields of science
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance