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anti-pseudoMOnas aeruginosa biofilm NAno-in-hydroGEL

Project description

Innovative hydrogel as a carrier to aid in the fight against Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa (PA) is a common gram-negative aerobic bacterium with advanced multidrug resistance mechanisms. It causes disease in plants, animals and humans and is associated with deadly hospital-acquired infections. PA can form biofilms, which are structured bacterial communities a thousand times less sensitive to antibiotics. Funded by the Marie Skłodowska-Curie Actions programme, the MONAGEL project proposes to combat PA biofilms by developing a hydrogel made of cross-linked lipid nanoparticles with encapsulated hydrophobic and hydrophilic active ingredients. The applicability and efficacy of the approach will be assessed in various cell lines and demonstrated on a co-culture epithelium/biofilm model as a proof of concept for further development.

Coordinator

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Net EU contribution
€ 174 806,40
Address
Inhoffenstrasse 7
38124 Braunschweig
Germany

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Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00