Cellular and Biophysical Approach to Understand the Cytokine-mediated Regulation of the Lysosomal Hydrolytic Capacity

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IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Auteurs: Silvia Gaggero , Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon , Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra
Publié dans: Science Immunology, 2022, ISSN 2470-9468
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.ade5686

Lysosomes: multifunctional compartments ruled by a complex regulatory network

Auteurs: Jonathan Martinez Fabregas Joaquin Tamargo Azpilicueta Irene Diaz Moreno
Publié dans: FEBS Open Bio, 2022, ISSN 2211-5463
Éditeur: Elsevier BV
DOI: 10.1002/2211-5463.13387

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation

Auteurs: Katiuska González-Arzola Antonio Díaz-Quintana Noelia Bernardo-García Jonathan Martínez-Fábregas Francisco Rivero-Rodríguez Miguel Á. Casado-Combreras Carlos A. Elena-Real Alejandro Velázquez-Cruz Sergio Gil-Caballero Adrián Velázquez-Campoy Elzbieta Szulc María P. Gavilán Isabel Ayala Rocío Arranz Rosa M. Ríos Xavier Salvatella José M. Valpuesta Juan A. Hermoso Miguel A. De la Rosa
Publié dans: Nature Structural and Molecular Biology, 2022, ISSN 1545-9993
Éditeur: Nature Publishing Group
DOI: 10.1038/s41594-022-00842-3

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