Cellular and Biophysical Approach to Understand the Cytokine-mediated Regulation of the Lysosomal Hydrolytic Capacity

Project Information

CytoLysoReg

Grant agreement ID: 101025429

DOI

10.3030/101025429

Project terminated on 31 December 2022

EC signature date 9 March 2021

Start date 1 September 2021

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 172 932,48

EU contribution

€ 172 932,48

Coordinated by

UNIVERSIDAD DE SEVILLA
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Author(s): Silvia Gaggero , Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon , Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra
Published in: Science Immunology, 2022, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.ade5686

Lysosomes: multifunctional compartments ruled by a complex regulatory network

Author(s): Jonathan Martinez Fabregas Joaquin Tamargo Azpilicueta Irene Diaz Moreno
Published in: FEBS Open Bio, 2022, ISSN 2211-5463
Publisher: Elsevier BV
DOI: 10.1002/2211-5463.13387

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation

Author(s): Katiuska González-Arzola Antonio Díaz-Quintana Noelia Bernardo-García Jonathan Martínez-Fábregas Francisco Rivero-Rodríguez Miguel Á. Casado-Combreras Carlos A. Elena-Real Alejandro Velázquez-Cruz Sergio Gil-Caballero Adrián Velázquez-Campoy Elzbieta Szulc María P. Gavilán Isabel Ayala Rocío Arranz Rosa M. Ríos Xavier Salvatella José M. Valpuesta Juan A. Hermoso Miguel A. De la Rosa
Published in: Nature Structural and Molecular Biology, 2022, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00842-3