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Genome-wide CRISPR/Cas9 screen in intestinal organoids for identification and molecular characterization of therapeutic targets to enhance tissue regeneration

Project description

CRISPR/Cas9 screening to identify regulators of tissue regeneration in inflammatory bowel disease

Inflammatory bowel disease is a devastating chronic inflammatory condition of the digestive tract characterised by severe damage to the intestinal epithelium. Therapeutic strategies have to promote epithelial repair to restore tissue integrity in addition to relieving symptoms of inflammation. The EU-funded ScrIntOR project aims to elucidate the cellular and molecular mechanisms involved in epithelial regeneration. The study will employ a unique in vitro organoid system that captures epithelial cells in a regenerative state in combination with large-scale CRISPR/Cas9 screening to identify novel regulators of intestinal regeneration. Moreover, ScrIntOR will validate key pathways in intestinal repair and dissect the interplay of molecular pathways that orchestrate tissue healing.

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution
€ 207 312,00
Address
Norregade 10
1165 Kobenhavn
Denmark

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00