CRISPR/Cas9 screening to identify regulators of tissue regeneration in inflammatory bowel disease
Inflammatory bowel disease is a devastating chronic inflammatory condition of the digestive tract characterised by severe damage to the intestinal epithelium. Therapeutic strategies have to promote epithelial repair to restore tissue integrity in addition to relieving symptoms of inflammation. The EU-funded ScrIntOR project aims to elucidate the cellular and molecular mechanisms involved in epithelial regeneration. The study will employ a unique in vitro organoid system that captures epithelial cells in a regenerative state in combination with large-scale CRISPR/Cas9 screening to identify novel regulators of intestinal regeneration. Moreover, ScrIntOR will validate key pathways in intestinal repair and dissect the interplay of molecular pathways that orchestrate tissue healing.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- natural sciencesbiological sciencescell biology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health sciencesbasic medicinepathology