Project description
Circulating microRNAs as novel biomarkers in the diagnosis of Lynch syndrome
The recent developments of liquid biopsy methods and analysis have turned blood-based cancer biomarkers into critical modern tools for cancer prevention and diagnosis. The cell-free non-coding circulating microRNA particles (c-miRs) associated with cancer development have been identified and tested in applications for cancer screening, diagnosis, tumour classification, treatment monitoring, and prediction of the outcome. However, c-miRs have not thus far been investigated in Lynch syndrome cohorts. The EU-funded cmiRCan project aims to use whole serum c-miR clusters from patients with hereditary cancer-associated Lynch syndrome as a biomarker. The interdisciplinary project will combine clinical, cell biological, and bioinformatics research to develop machine learning-based algorithms to diagnose and predict cancer occurrence in the Lynch syndrome patient cohort.
Objective
Blood-based cancer biomarkers have become important research targets and together with the recent development of liquid biopsy methods and analysis, they have become interesting future tools for cancer diagnosis. The cell-free small non-coding circulating RNA particles, namely microRNAs (c-miRs) that associate with cancer development, have been identified and tested to be used for cancer screening, diagnosis, tumor subtype classification, chemo- or radio-resistance monitoring, and outcome prognosis. Here we use whole serum c-miR clusters from patients with hereditary cancer syndrome, called Lynch syndrome, as a biomarker and we develop machine learning-based algorithms to diagnose and predict cancer occurrence in this patient cohort. We also functionally test how these c-miR clusters effect lynch syndrome linked to tumor growth.
This interdisciplinary project combines clinical, cell biological and bioinformatic research and it will reciprocally transfer knowledge between research, Tiina Jokela and host institute, University of Jyväskylä and secondment institutes; University of Helsinki and Helsinki University Hospital. The proposed project support researcher Tiina Jokela to also gain transferable independent research skills and support her future career goal to become the leader of her own academic research group in the cancer research field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
40100 Jyvaskyla
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.