Project description
Bioprinting: the future of transplantation
Tissue bioprinting is a novel technology that uses biomaterials to produce constructs for potential clinical use. This approach is expected in the future to address the shortage of donor tissues and organs needed to treat many chronic diseases. INKspired is an EU-funded initiative that will advance bioprinting by developing bioinks based on the extracellular matrix that also combine the capacity to modulate the immune response. This will help recreate the native complexity of tissues more accurately and improve the mechanical and biological properties of printed constructs. Importantly, it will bring bioprinting one step closer to generating implantable living tissues.
Objective
Tissue and organ shortage is the limiting factor in treating many patients with chronic organ failure and has led to over 18 patients deaths every day just in Europe. Recreating the 3D complexity of tissues and organs is moving step-by-step from sci-fi to reality thanks to the tremendous progress in 3D printing techniques. Native tissues and organs are composed of different cells, proteins, and signaling molecules that are arranged in a hierarchical complex microenvironment, called extracellular matrix (ECM). Bioprinting has emerged as a novel fabrication technique that assembles cells-laden biomaterials in a spatially controlled manner, promising customized 3D tissue-engineered constructs for potential clinical use. One of the main challenges to clinical success is to avoid immune system rejection. The overall aim of the INKspired project is to generate novel ECM-inspired bioinks, which could further recapitulate the dynamicity and complex structure of native tissue and even modulate the immune response. By double network strategy, I will combine two dynamic hydrogel networks to control the overall mechanical and biological properties of printed constructs. The outcomes of INKspired aim to contribute to tissue bioprinting and hence the global chronic lack of tissues.
My unique research background, which includes tissue engineering, material science and engineering, will allow me to carry out this multidisciplinary project. I will collaborate with the supervisors, who have a vast experience in biofabrication and biomaterials, and work at the international and interdisciplinary setting (MERLN, Maastricht University). Marie Curie fellowship will enhance the potential of my future career perspectives by providing an interdisciplinary and translational education program, empowering me to take leading positions in the field of tissue engineering worldwide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences basic medicine immunology
- engineering and technology mechanical engineering manufacturing engineering additive manufacturing
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6200 MD Maastricht
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.