Project description
Role of CD28 receptor in T-cell stimulation
Understanding T-cells regulation is critical for the development of a broad spectrum of therapeutics. The mechanisms of activation/repression of T cells depend on receptors providing secondary signals following the initial interaction with antigen-presenting cells displaying antigens bound by major histocompatibility complex proteins. CD28 receptor acts as a co-stimulator of T-cell activity. The EU-funded CD28 project will explore the possible role of sialic acid in regulating CD28 co-stimulatory activity via the so-called neuraminidase effect. The structural basis for CD28 regulation will also be explored, creating molecular platforms which may serve for reactivation of exhausted T cells in tumour models.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF-GF - Global FellowshipsCoordinator
48160 Derio Vizcaya
Spain
See on map
Partners (1)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
92037 1000 La Jolla
See on map