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Probing CD28 as checkpoint for T cell co-stimulation in cancer and infection

Project description

Role of CD28 receptor in T-cell stimulation

Understanding T-cells regulation is critical for the development of a broad spectrum of therapeutics. The mechanisms of activation/repression of T cells depend on receptors providing secondary signals following the initial interaction with antigen-presenting cells displaying antigens bound by major histocompatibility complex proteins. CD28 receptor acts as a co-stimulator of T-cell activity. The EU-funded CD28 project will explore the possible role of sialic acid in regulating CD28 co-stimulatory activity via the so-called neuraminidase effect. The structural basis for CD28 regulation will also be explored, creating molecular platforms which may serve for reactivation of exhausted T cells in tumour models.

Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Net EU contribution
€ 245 732,16
Address
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Spain

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Region
Noreste País Vasco Bizkaia
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE SCRIPPS RESEARCH INSTITUTE CORPORATION
United States
Net EU contribution
€ 0,00
Address
North Torrey Pines Road 10550
92037 1000 La Jolla

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 165 265,92