Role of CD28 receptor in T-cell stimulation
Understanding T-cells regulation is critical for the development of a broad spectrum of therapeutics. The mechanisms of activation/repression of T cells depend on receptors providing secondary signals following the initial interaction with antigen-presenting cells displaying antigens bound by major histocompatibility complex proteins. CD28 receptor acts as a co-stimulator of T-cell activity. The EU-funded CD28 project will explore the possible role of sialic acid in regulating CD28 co-stimulatory activity via the so-called neuraminidase effect. The structural basis for CD28 regulation will also be explored, creating molecular platforms which may serve for reactivation of exhausted T cells in tumour models.
Fields of science
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
92037 1000 La Jolla
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