Dissecting the mechanism of the regulation of γTuRC-mediated microtubule nucleation

Project description

Mechanistic insight into cytoskeleton regulation

The microtubule cytoskeleton plays an important role in cell architecture and function. Microtubule nucleation is a regulated process governed by the γ-tubulin ring complex (γTuRC). The scope of the EU-funded TuRCreg project is to dissect the molecular mechanism of γTuRC-mediated nucleation using recent technological advancements in biochemistry, microscopy, and structural biology. The project's results will provide fundamental information on the cytoskeletal organisation and dynamics in cells and help scientists understand how the microtubule cytoskeleton is implicated in certain diseases. Long-term project results will pave the way for the identification of novel therapeutic targets.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › cell biology
• natural sciences › physical sciences › optics › microscopy
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › molecular biology › structural biology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA

Net EU contribution

€ 160 932,48

Address

Carrer Doctor Aiguader 88
08003 Barcelona
Spain

Region

Este › Cataluña › Barcelona

Activity type

Research Organisations

Links

Non-EU contribution

€ 0,00