Project description
Exercise as a preventive means for metastatic tumour recurrence in colorectal cancer patients
Colorectal cancer (CRC) is the second most common cancer in Europe, and the cause of death for nearly 230,000 Europeans every year. Around 30 % of CRC patients develop liver metastases, which constitute the main cause of death among this patient population. As exercise has been proven to exert anti-tumour effects and inhibit tumour growth in animal models, physical activity could be an excellent complementary treatment alongside the pharmacological anti-cancer treatment. The EU-funded POET-mCRC project aims to investigate whether long-term exercise can prevent or delay metastasis recurrence in CRC patients. In addition, it aims to identify the optimal dose of exercise required to obtain these beneficial effects.
Objective
Every year nearly 228,000 individuals die from colorectal cancer (CRC) in Europe, the second most common cancer in Europe. Around 30% of the CRC patients develop liver metastases and these are the main cause of death. Removal of liver metastatic tumors is the primary treatment method for CRC, however, 50-75% of the patients experience a relapse of the metastases within two years, rendering adjunct treatment strategies necessary for these patients.
Preclinical work has demonstrated that exercise exerts anti-tumor effects as it is indeed able to inhibit tumor growth. Thus, exercise constitutes an excellent candidate as a complementary to the pharmacological treatment approach for CRC metastatic patients (mCRC).
My primary aim is to investigate the effects of chronic exercise on tumor recurrence after liver metastasis removal. Secondary aims are to identify the “optimal dose” of exercise to obtain the largest beneficial effect and explore the changes on circulating tumor DNA (ctDNA) as a marker of disease progression. I hypothesize that exercise training will delay or ameliorate disease recurrence in mCRC patients.
Patients will be randomized to 3 groups: control, group 1(300 min/week), group 2 (150 min/week) of combined aerobic and strength exercise training for 6 months. Study endpoints will be tumor recurrence, inflammation and immune markers, physiological adaptations and ctDNA changes.
The outcomes will provide essential knowledge about how to optimize the guidelines for exercise prescription as part of the treatment plan for mCRC patients.
The fellowship will be vital for my reintegration into academia and for me to evolve as a lead researcher. It also constitutes an ideal means of knowledge transfer between myself and the host organization as I will gain knowledge in the oncology area and advance my skills in molecular biology techniques while I convey my experience in dose-response methodology and the conduct of large-scale human exercise trials.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3400 Hillerod
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.