Projektbeschreibung
Körperliche Bewegung als präventive Maßnahme gegen metastasierende Tumorrezidive bei Darmkrebskranken
Darmkrebs ist die zweithäufigste Krebsart in Europa und verursacht alleine in Europa rund 230 000 Todesfälle pro Jahr. Rund 30 % aller Darmkrebsbetroffenen entwickeln Metastasen der Leber, die bei dieser Krankengruppe die häufigste Todesursache darstellen. Da in Tiermodellen nachgewiesen werden konnte, dass körperliche Bewegung Anti-Tumor-Wirkungen hat und das Tumorwachstum hemmt, könnte körperliche Betätigung eine ausgezeichnete Komplementärbehandlung zur pharmakologischen Krebsbehandlung darstellen. Das EU-finanzierte Projekt POET-mCRC möchte untersuchen, ob Bewegung über einen längeren Zeitraum Metastasenrezidive bei Darmkrebskranken verhindern oder hinauszögern kann. Ferner will es die optimale Menge an Bewegung ermitteln, um diese vorteilhaften Effekte zu erzielen.
Ziel
Every year nearly 228,000 individuals die from colorectal cancer (CRC) in Europe, the second most common cancer in Europe. Around 30% of the CRC patients develop liver metastases and these are the main cause of death. Removal of liver metastatic tumors is the primary treatment method for CRC, however, 50-75% of the patients experience a relapse of the metastases within two years, rendering adjunct treatment strategies necessary for these patients.
Preclinical work has demonstrated that exercise exerts anti-tumor effects as it is indeed able to inhibit tumor growth. Thus, exercise constitutes an excellent candidate as a complementary to the pharmacological treatment approach for CRC metastatic patients (mCRC).
My primary aim is to investigate the effects of chronic exercise on tumor recurrence after liver metastasis removal. Secondary aims are to identify the “optimal dose” of exercise to obtain the largest beneficial effect and explore the changes on circulating tumor DNA (ctDNA) as a marker of disease progression. I hypothesize that exercise training will delay or ameliorate disease recurrence in mCRC patients.
Patients will be randomized to 3 groups: control, group 1(300 min/week), group 2 (150 min/week) of combined aerobic and strength exercise training for 6 months. Study endpoints will be tumor recurrence, inflammation and immune markers, physiological adaptations and ctDNA changes.
The outcomes will provide essential knowledge about how to optimize the guidelines for exercise prescription as part of the treatment plan for mCRC patients.
The fellowship will be vital for my reintegration into academia and for me to evolve as a lead researcher. It also constitutes an ideal means of knowledge transfer between myself and the host organization as I will gain knowledge in the oncology area and advance my skills in molecular biology techniques while I convey my experience in dose-response methodology and the conduct of large-scale human exercise trials.
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