Project description
Transdermal drug delivery system for the treatment of skin malignancies
The main goal of the EU-funded GELNANODEP project is to introduce a complex anticancer treatment approach by developing a bio-gel loaded with bacteriophages and nanoparticles with encapsulated active bio-compounds. The project objective is to exploit the innovative approach to avoid the usual side effects associated with oral and injectable anticancer pharmaceuticals. This transdermal drug delivery system represents a promising avenue for treating skin tumours. The GELNANODEP system will include a thermosensitive, biodegradable and biocompatible polymer bio-gel, carrying engineered nanoparticles for specific targeting of tumour cell alpha 2-beta-3 integrin. Other components include the potent anticancer agent isothiocyanate sulforaphane and natural bacteriophages, targeting pathogenic bacteria that are frequently associated with chronic inflammation in skin malignancies.
Objective
GELNANODEP aims at inserting in the background of the advance drug delivery systems an innovative clinical treatment for skin cancer diseases as melanoma. The main goal of GELNANODEP system is to exploit a synergic therapeutic anticancer approach by using a gel depot loaded natural bacteriophages and a natural bio compound encapsulated with surface engineering nanoparticles. This project intends to propose a novel and alternative approach to avoid the usual severe side-effects affected by the systemic administration of the anticancer pharmaceuticals (e.g. intravenous injections or oral). So, the transdermal drug delivery system is proposed as alternatives that offer promising strategies for the treatment of skin tumours. Melanoma is a skin cancer which can become metastatic, drug-refractory, and lethal if managed late or inappropriately. Besides these already complicated conditions, it is largely known how the depletion of the immunological defence system of the cancer patient can induce infections by opportunist microbial pathogens such as bacteria and fungi. Pathogenic microorganisms with cancers have been reported frequently associated with chronic inflammation in skin malignancies, which can promote skin carcinogenesis inducing the ulceration of cutaneous lesions, and last but not list increasing patient mortality.
The GELNANODEP system provides a depot based on a thermosensitive biodegradable and biocompatible triblock copolymer carrying: (I) surface engineered nanoparticles to specific target alpha 2-beta-3 integrin expressed on tumour cells and selective release sulforaphane which is a natural dietary isothiocyanate mostly characterized by its potent anticancer activity, and (II) naturally bacteriophages inducing the death of pathogenic bacteria.
This proposal will be pursued by a highly interdisciplinary skills, composed of pharmaceutics, polymer chemistry, biology, molecular biology, oncology, clinicals and microbiology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences microbiology mycology
- natural sciences chemical sciences polymer sciences
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2573 HT 's-Gravenhage (Den Haag)
Netherlands
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.