Pathogenesis and the secretion systems of Mycobacterium tuberculosis
An estimated one quarter of the world’s population is infected with Mycobacterium tuberculosis (Mtb). Mtb is highly efficient as a pathogen due to its distinct and hydrophobic outer membrane (OM) and type VII secretion systems (T7SSs). There are five T7SSs that perform different functions such as immunomodulation, virulence and nutrient uptake, and four conserved membrane components which form a hexameric inner membrane complex, with a fifth transiently interacting membrane component called MycP. The EU-funded CryoMyco project aims to elucidate the mechanism of secretion through the Mtb cell envelope by deciphering the high-resolution structure of the hexameric T7SS membrane complex as well as the molecular and structural mechanisms behind the OM translocation process.