Atomic dissection of type VII secretion systems from pathogenic mycobacteria

Project description

Pathogenesis and the secretion systems of Mycobacterium tuberculosis

An estimated one quarter of the world’s population is infected with Mycobacterium tuberculosis (Mtb). Mtb is highly efficient as a pathogen due to its distinct and hydrophobic outer membrane (OM) and type VII secretion systems (T7SSs). There are five T7SSs that perform different functions such as immunomodulation, virulence and nutrient uptake, and four conserved membrane components which form a hexameric inner membrane complex, with a fifth transiently interacting membrane component called MycP. The EU-funded CryoMyco project aims to elucidate the mechanism of secretion through the Mtb cell envelope by deciphering the high-resolution structure of the hexameric T7SS membrane complex as well as the molecular and structural mechanisms behind the OM translocation process.

Fields of science

• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › clinical medicine › pneumology › tuberculosis

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Net EU contribution

€ 174 806,40

Address

Martinistrasse 52
20251 Hamburg
Germany

Region

Baden-Württemberg › Stuttgart › Stuttgart, Stadtkreis

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 174 806,40