The SCENARIOS project, funded under the Zero Pollution Topic 8.1 of the Green Deal, focuses on addressing the pollution caused by per- and polyfluoroalkyl substances (PFAS) in soil, vadose zone, and water. PFAS are persistent and toxic chemicals widely used in industrial and consumer products, posing significant risks to human health and the environment. The project aims to develop comprehensive technological solutions for detection, monitoring, risk assessment, pollution control, and remediation of PFAS. PFAS contamination in water sources, soil, and air is a global issue with detrimental effects on ecosystems and human health. The project emphasizes the need for toxicological research to understand the impacts of PFAS exposure and guide effective risk management strategies. While certain PFAS compounds are being regulated and phased out in some regions, there are still knowledge gaps regarding their toxicology and potential alternatives. Robust toxicological studies are crucial for evidence-based regulations, establishing safe exposure limits, and developing less harmful alternative chemicals. Conventional remediation methods for PFAS are often ineffective, highlighting the need for innovative approaches informed by advancements in PFAS toxicology research. The SCENARIOS project focuses on the development of efficient and cost-effective remediation technologies that consider PFAS behavior, fate, and associated risks. It aims to develop cutting-edge technologies for detection, quantification, control, and remediation of PFASs in different environmental compartments. The project also seeks to develop solutions for pollution control and remediation of PFAS-contaminated drinking water, agricultural soils, and groundwater, aligning with principles of green chemistry, sustainability, and circular economy. Additionally, SCENARIOS aims to improve human health and ecosystem protection by building a detailed knowledge base on PFAS impacts and exposure. This will be achieved through a cross-toxicological approach, integrating molecular systems biology, toxicogenomics, phenotypic screening, bioinformatics, and cheminformatics. The project has three specific goals: implementing a rapid and accurate method for PFAS detection, expanding the environmental risk assessment framework for non-regulated PFAS and mixtures, and developing integrated technical and biological remediation strategies. The SCENARIOS project aims to demonstrate its solutions in various industrial and public health settings to promote contaminant remediation and health monitoring, aligning with the goals of the Green Deal.