Strategies for health protection, pollution Control and Elimination of Next generAtion RefractIve Organic chemicals from the Soil, vadose zone and water

Deliverables

This Deliverable consists of the SCENARIOS Workshop Series (O, OTHER) planned along the project (three events). This report will gather each workshop agenda, outcomes, number of attendees and impacts (Output Task 10.4). The Deliverable will be due at M18 and updated in further Reports to the EC at M30 and 44.Deliverables also at M30, M44

SCENARIOS public communication materials (Intermediate)

This deliverable is the updated version of a collection of materials (O, OTHERS) produced for SCENARIOS communication (Input and Output Task, 10.1-10.5)

SCENARIOS project website

Launch of the project Website (O, Other). Moreover, Scenarios social networks will be created. A Report with information on the website will be also delivered. Main Input and Output Task is 10.1

SCENARIOS public communication materials (Draft)

This deliverable is a collection of materials (O, OTHERS) produced for SCENARIOS communication, including a poster, a project presentation, a brochure and annual newsletters (Input and Output Task, 10.1-10.5)

Installation of monitoring systems for the unsaturated zone and groundwater at selected sites

A prototype vadose zone monitoring systems (VMS) for the study of PFAS transport will be installed and validated at real demo sites. An accompanying report featuring characteristic and performance will be prepared by Partner 4 (BGU) in collaboration with partner 5 (FOR), Partner 15 (ENV) and partner 17 (GEO). Input and output Tasks are T3.1 and T3.2.

Coordinated Policy Briefs on PFAS regulation

A brief Report will provide a practical structure to include the relevant information regarding the state-of-the-art policies on PFAS remediation. The deliverable will systematize the current large-scale regulations and highlight the agreement among operative procedures and requirements at local level, with special attention to gaps arising from lack of data, risk thresholds, and prescriptions. These results will be organised in order to identify the main gaps that can be covered by SCENARIOS solutions with regard to data acquisition and accessibility, LCA assessment, and new remediation solutions. Output Task 9.5. Input Task 9.5, T8.1-8.8. This Deliverable has the potential to contribute to new policy within the EU.Strong contribution to policy expected.

Report on LCA & LCC Results for SCENARIOS strategies

The deliverable is a Report -due at M12 (Draft version) and M36 (Final version)- conforming Output Task 8.1, Environmental Impact and Life Cycle Assessmentand Task 8.2, Economic Evaluation and Life Cycle Costing. Input Tasks are 8.1, 8.2, with possible inputs also from T6.1-6.4 and T7.3-7.4.Strong contribution to policy expected for approaches to address PFAS fate and costs in the environment. Each report will be structured as an LCA report presenting the results as indicated by ISO 14040. The systems to be evaluated with LCA will be defined according to the DEMOs realized in WP 7. For each system, the deliverable will describe all the elements necessary for the transparency of the LCA (scope functional unit, system boundaries, assumptions, data used for the analysis, software and databases applied, impact categories and impact assessment method, normalization and weighting strategies) and the associated results. Moreover, for the assessment of the Lifecycle Costing, Cost models, pricing systems and databases applied will be described.

Coordinated Policy briefs on risk assessment

Deliverable D99 will consist of a short document R Report that summarizes all the main findings available from the current literature and preliminary results on human and environmental hazardrisk assessments in respect to the current chemical legislation Eg REACHCLP Deliverable D47 will rely on the results and inputs from Tasks 41 to 48 it will conform Task 47 as well as T95 on regulation as output TasksStrong contribution to policy expected

SOP for sample storage and handling

The validated methodsprotocols for shipping storing and handling of samples will be described in a scientific report R report based on Task 21 Output Task The different sampling requirements for each type of sample water wastewater soil etc will be considered Subtask 211 and 212 The content of this report will serve as input for sample preparationhandling for multiple tasks in WP2 WP3 WP4 WP6 and WP7

Publications

Generic method for the detection of short & long chain PFAS extended to the lowest concentration levels of SERS capability

Author(s): Zoi G. Lada, Georgios N. Mathioudakis, Amaia Soto Beobide, Konstantinos S. Andrikopoulos, George A. Voyiatzis
Published in: Chemosphere, Issue 363, 2024, Page(s) 142916, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2024.142916

Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications

Author(s): Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli, Francesco Dondero
Published in: Journal of Xenobiotics, Issue 14, 2024, Page(s) 1771-1783, ISSN 2039-4713
Publisher: MDPI
DOI: 10.3390/jox14040094

Sensitive and accurate determination of 32 PFAS in human serum using online SPE-UHPLC-HRMS

Author(s): Masho Hilawie Belay, Elisa Robotti, Arianna Ghignone, Alessia Fabbris, Jessica Brandi, Daniela Cecconi, Maria Angela Masini, Francesco Dondero, Emilio Marengo
Published in: Journal of Hazardous Materials, Issue 485, 2024, Page(s) 136780, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.136780

Effects of Ether Perfluoro Carboxyl Acids (PFECAs) on Innate Immunity in Earthworms (Eisenia fetida)

Author(s): Davide Gualandris, Davide Rotondo, Candida Lorusso, Valentina Audrito, Antonio Calisi, Francesco Dondero
Published in: Environments, Issue 12, 2025, Page(s) 430, ISSN 2076-3298
Publisher: MDPI AG
DOI: 10.3390/environments12110430

Parameter grouping and co-estimation in physiologically based kinetic models using genetic algorithms

Author(s): Periklis Tsiros, Vasileios Minadakis, Dingsheng Li, Haralambos Sarimveis
Published in: Toxicological Sciences, Issue 200, 2024, Page(s) 31-46, ISSN 1096-6080
Publisher: Oxford University Press
DOI: 10.1093/toxsci/kfae051

Multi-compound PFAS transport in the unsaturated zone during infiltration cycles

Author(s): Samuel Oluwaseun Kolade, Avner Ronen, Tuvia Turkeltaub, Christos Tsakiroglou, Knud Erik Strøyberg Klint, Prerona Das, Ofer Dahan
Published in: Water Research, Issue 288, 2025, Page(s) 124463, ISSN 0043-1354
Publisher: Elsevier BV
DOI: 10.1016/j.watres.2025.124463

Predicting peroxisome proliferator-activated receptor gamma potency of small molecules: a synergistic consensus model and deep learning binding affinity approach powered by Enalos Cloud Platform

Author(s): Maria Antoniou, Konstantinos D. Papavasileiou, Antreas Tsoumanis, Georgia Melagraki, Antreas Afantitis
Published in: Molecular Diversity, 2025, ISSN 1381-1991
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11030-025-11230-6

Evaluation of per- and polyfluoroalkyl substances (PFAS) toxic effects on the acute inflammatory response in the medicinal leech Hirudo verbana

Author(s): A. Calisi, N. Baranzini, G. Marcolli, C. Bon, D. Rotondo, D. Gualandris, L. Pulze, A. Grimaldi, F. Dondero
Published in: Chemosphere, Issue 366, 2024, Page(s) 143519, ISSN 0045-6535
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2024.143519

Titania: an integrated tool for in silico molecular property prediction and NAM-based modeling

Author(s): Nikoletta-Maria Koutroumpa, Maria Antoniou, Dimitra-Danai Varsou, Konstantinos D. Papavasileiou, Nikolaos K. Sidiropoulos, Christoforos Kyprianou, Andreas Tsoumanis, Haralambos Sarimveis, Iseult Lynch, Georgia Melagraki, Antreas Afantitis
Published in: Molecular Diversity, Issue 29, 2025, Page(s) 3555-3573, ISSN 1381-1991
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11030-025-11196-5

Degradation of organic pollutants combining plasma discharges generated within soil with TiO2 and ZnO catalysts: Comparative analysis, optimization and mechanisms

Author(s): M. Hatzisymeon, M.K. Daletou, G. Rassias, C.A. Aggelopoulos
Published in: Separation and Purification Technology, Issue Volume 320, 1 September 2023, 124119, 2023, Page(s) Article number 124119, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2023.124119

Screening uncalibrated priority pollutants by improved AHP-CRITIC method at development land

Author(s): Xinni Wei, Xiuli Dang, Peng Liu, Ge Gao, Hang Zhu, Jiayue Shi, Qiyuan Zhang, Roland Bol, Peng Zhang, Iseult Lynch, Long Zhao
Published in: Environment International, Issue 202, 2025, Page(s) 109650, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109650

Effects of Perfluorooctanoic Acid (PFOA) on Colony Growth, Bioluminescence, and Swarming Motility of Vibrio campbellii and Quorum-Sensing Defective Mutants

Author(s): Matteo Calcagnile, Andrea Giuliano, Fabio Paladini, Stefania Villani, Salvatore Maurizio Tredici, Francesco Dondero, Vincenzo Nassisi, Pietro Alifano
Published in: Applied Microbiology, Issue 5, 2025, Page(s) 143, ISSN 2673-8007
Publisher: MDPI AG
DOI: 10.3390/applmicrobiol5040143

Mechanisms of Individual and Simultaneous Adsorption of Antibiotics and Dyes onto Halloysite Nanoclay and Regeneration of Saturated Adsorbent via Cold Plasma Bubbling

Author(s): Stefania Giannoulia; Irene-Eva Triantaphyllidou; Athanasia G. Tekerlekopoulou; Christos A. Aggelopoulos
Published in: Nanomaterials, Issue 13, 2023, Page(s) 341, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13020341

A Review on Removal and Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Novel Membranes

Author(s): Suman Das, Avner Ronen
Published in: Membranes, Issue Membranes 2022, 12, 662, 2022, ISSN 2077-0375
Publisher: Molecular Diversity Preservation International
DOI: 10.3390/membranes12070662

Exploration of cephalexin adsorption mechanisms onto bauxite and palygorskite and regeneration of spent adsorbents with cold plasma bubbling

Author(s): S. Giannoulia, A. G. Tekerlekopoulou, C. A. Aggelopoulos
Published in: Applied Water Science, Issue 14, 2024, ISSN 2190-5487
Publisher: Springer Nature
DOI: 10.1007/s13201-024-02101-w

Key-study on plasma-induced degradation of cephalosporins in water: Process optimization, assessment of degradation mechanisms and residual toxicity

Author(s): S. Meropoulis, S. Giannoulia, S. Skandalis, G. Rassias, C.A. Aggelopoulos
Published in: Separation and Purification Technology, Issue Volume 2981, October 2022, 2022, Page(s) Article number 121639, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.seppur.2022.121639

A Systematic Review of Deep Learning Methodologies Used in the Drug Discovery Process with Emphasis on In Vivo Validation

Author(s): Nikoletta-Maria Koutroumpa, Konstantinos D. Papavasileiou, Anastasios G. Papadiamantis, Georgia Melagraki, Antreas Afantitis
Published in: International Journal of Molecular Sciences, Issue Int. J. Mol. Sci. 2023, 24, 6573, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076573

A novel, green, low-cost regeneration method for surface enhanced raman scattering (SERS) solid substrates based on nanosecond pulsed cold plasma technology

Author(s): Z.G. Lada, G.A. Voyiatzis, C.A. Aggelopoulos
Published in: Surfaces and Interfaces, Issue Volume 34, November 2022, 2022, Page(s) Article number 102330, ISSN 2468-0230
Publisher: Elsevier
DOI: 10.1016/j.surfin.2022.102330

Reactive species and mechanisms of perfluorooctanoic acid (PFOA) degradation in water by cold plasma: The role of HV waveform, reactor design, water matrix and plasma gas

Author(s): K. Papalexopoulou, X. Huang, A. Ronen, C.A. Aggelopoulos
Published in: Separation and Purification Technology, Issue 342, 2024, Page(s) 126955, ISSN 1383-5866
Publisher: Pergamon Press Ltd.
DOI: 10.5281/zenodo.14611262

Development of a Robust Read-Across Model for the Prediction of Biological Potency of Novel Peroxisome Proliferator-Activated Receptor Delta Agonists

Author(s): Maria Antoniou, Konstantinos D. Papavasileiou, Georgia Melagraki, Francesco Dondero, Iseult Lynch, Antreas Afantitis
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 5216, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25105216

Generic Method for the Detection of Short & Long Chain Pfas Extended to the Lowest Concentration Levels of Sers Capability

Author(s): Zoi Lada, Georgios Mathioudakis, Amaia Soto Beobide, Konstantinos Andrikopoulos, George Voyiatzis
Published in: Chemosphere, Issue 363, 2024, Page(s) 142916, ISSN 1879-1298
Publisher: Elsevier
DOI: 10.2139/ssrn.4887145

Impact of Short-Chain Perfluoropropylene Oxide Acids on Biochemical and Behavioural Parameters in Eisenia fetida (Savigny, 1826)

Author(s): Davide Rotondo, Davide Gualandris, Candida Lorusso, Albert Braeuning, Antonio Calisi, Francesco Dondero
Published in: Journal of Xenobiotics, Issue 15, 2024, Page(s) 2, ISSN 2039-4713
Publisher: MDPI
DOI: 10.3390/jox15010002

Recent Advances in Computational Modeling of BACE1 Inhibitors as Anti-Alzheimer Agents

Author(s): Konstantinos D. Papavasileiou, Francesco Dondero, Georgia Melagraki, Antreas Afantitis
Published in: Neuromethods, Computational Modeling of Drugs Against Alzheimer’s Disease, 2023, Page(s) 73-97
Publisher: Springer US
DOI: 10.1007/978-1-0716-3311-3_3

Bioconversion of hazardous organic wastes using invertebrates

Author(s): Angie M. Pedraza Torres, Juan C. Sanchez-Hernandez
Published in: Fate of Biological Contaminants During Recycling of Organic Wastes, Issue Chapter Fifteen, 2023, Page(s) Pages 297-357, ISBN 978-0-323-95998-8
Publisher: Elsevier
DOI: 10.1016/b978-0-323-95998-8.00007-8

Deliverables

Publications

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