Objective
Congenital Heart Disease (CHD) results when the heart abnormally develops before birth. With diminished cardiac function, the heart fails to supply the required oxygenated blood to the body, causing a cascade of failures at different scales that prevent the newborn from growing normally. Even with improved surgical and medical treatments, CHD remains a lifelong risk factor for many diseases.
An emerging application in cardiac tissue engineering is the 3D bioprinting of human hearts, or their parts, for clinical transplantation, with CHD representing a potential therapeutic target. Whereas the fabrication of bioartificial hearts is currently feasible, there remain significant scientific and technological challenges that yet need to be overcome. The development of novel experimental approaches is fundamental. At the same time, there is a pressing need for complementary computational methods to efficiently assist in the design of biophysically feasible and printable hearts, which must necessarily grow with the CHD patient's body while adapting to lifelong changes in hemodynamic conditions.
In this project, therefore, I will develop a highly novel and interrelated experimental and computational approach for reproducing and predicting growing conditions of bioengineered hearts. The ambitious experimental design will enhance the maturation of cardiac muscle and biomechanical function of bioprinted ventricles in dynamic bioreactors. The highly-coupled multi-physics computational platform will describe these complex processes under multiple stimulated conditions to, ultimately, predict the critical adaptation and evolution of bioengineered ventricles potentially implanted in CHD patients. Therefore, by integrating ground-breaking methods within an extremely complex scenario, G-CYBERHEART will cross boundaries to drive advances in regenerative medicine and tissue engineering that will help accelerate the development of the bioengineered heart of the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
46022 VALENCIA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.