Artificial Lanthanide Enzymes for Selective Photocatalysis: 'Enlightening' Metalloenzyme Design and Evolution

Project Information

PhotoLanZyme

Grant agreement ID: 101039592

DOI

10.3030/101039592

EC signature date 11 April 2022

Start date 1 May 2022

End date 30 April 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Publications

Peer reviewed articles (4)

Modular protein scaffold architecture and AI-guided sequence optimization facilitate de novo metalloenzyme engineering

Author(s): Paula Wagner Egea; Florent Delhommel; Ghulam Mustafa; Florian Leiss-Maier; Lisa Klimper; Thomas Badmann; Anna Heider; Idoia Wille; Michael Groll; Michael Sattler; Cathleen Zeymer
Published in: Structure, Issue 34, 2026, ISSN 1878-4186
Publisher: Cell Press
DOI: 10.1016/J.STR.2025.10.010

A Luminescence-Based Screening Platform for Lanthanide-Binding Peptides and Proteins

Author(s): Robert Klassen; Anna Heider; Hannah Kugler; Michael Groll; Cathleen Zeymer
Published in: ACS Chemical Biology, Issue 20, 2025, ISSN 1554-8937
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSCHEMBIO.5C00670

Computational redesign and directed evolution of a lanthanide-dependent photoredox enzyme for enantioselective diol cleavage

Author(s): Florian Leiss-Maier, Joshua Behringer, Ghulam Mustafa, Anna Heider, Rahel Mühlhofer, Andreas S. Klein, Michael Groll, Cathleen Zeymer
Published in: Chemical Science, 2026, ISSN 2041-6520
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5SC08010J

A De Novo Metalloenzyme for Cerium Photoredox Catalysis

Author(s): Andreas Sebastian Klein, Florian Leiss-Maier, Rahel Mühlhofer, Benedikt Boesen, Ghulam Mustafa, Hannah Kugler, Cathleen Zeymer
Published in: Journal of the American Chemical Society, Issue 146, 2024, ISSN 0002-7863
Publisher: American Chemical Society (ACS)
DOI: 10.1021/JACS.4C04618