Objective
Growth-induced pressure necessarily emerges when a cell population, whichever the organism, proliferates in a 3D spatially-limited environment. Growth-induced pressure imposes physical constraints on cell physiology. A reduction of growth and division is observed in evolutionarily distant organisms such as bacteria, fungi, plants, or mammals. However, some cells are more capable of coping with these physical limitations and proliferate than others. This is in particular the case of cancer cells, for which growth-induced pressure participates in tumorigenesis and chemoresistance. Despite its importance, we are still at a loss to identify the basic sensing mechanisms associated with 3D proliferation under pressure.
It is notably unclear if the mechanical control of proliferation stems from specific signaling or is a consequence of associated changes in the physical properties of cells. The goal of UnderPressure is to elucidate the phenotypic convergence of the mechanical-control of cell proliferation. We hypothesize that a large part of proliferation reduction comes from the physical limits imposed by the obligatory increase of macromolecular crowding under 3D confinement. Crowding relates to the high fraction of macromolecules in the cell and has the potential to kinetically alter biochemical reactions. We expect crowding to limit key processes associated with growth and division, and to elicit specific signaling essential to circumvent these limitations.
Using unique microfluidic devices, we will investigate in bacteria, fungi, and mammalian cells how compressive forces physically limit growth and division and unravel the signaling pathways associated with the control of cell proliferation. We will mainly focus on crowding, investigate its consequences and its link with other physical properties such as membrane tension. We will use this knowledge to control cell proliferation in 3D compressed tumors, with the hope to notably reduce chemoresistance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.