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Enzyme-Mediated Dynamic Combinatorial Chemistry

Project description

Using templates to direct enzymatic synthesis

In nature, biomolecular templates define the outcomes of enzymatic reactions in some of the most fundamental biological processes, such as DNA replication, transcription and translation. The EU-funded ENZYME-DCC project will investigate the possibility of using synthetic (artificial) templates to direct enzymatic reactions and access different products to those formed in nature. The researchers will explore a conceptually new approach to using enzymes for chemical synthesis that involves combining tools and concepts from synthetic chemistry with enzymology. In this new methodology, enzymes catalyse reversible reactions and generate complex dynamic mixtures of interconverting products. Artificial template molecules will then be added to recognise and select the desired products from the mixtures.


Net EU contribution
€ 1 499 993,00
Anker Engelunds Vej 101
2800 Kongens Lyngby

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Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 4,00