Probing (Orphan) Nuclear Receptors in Neurodegeneration

Información del proyecto

NeuRoPROBE

Identificador del acuerdo de subvención: 101040355

DOI

10.3030/101040355

Fecha de la firma de la CE 26 Abril 2022

Fecha de inicio 1 Mayo 2022

Fecha de finalización 30 Abril 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 498 813,00

Aportación de la UE

€ 1 498 813,00

Coordinado por

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design

Autores: Úrsula López-García; Jan Vietor; Julian A. Marschner; Jan Heering; Vasily Morozov; Thomas Wein; Daniel Merk
Publicado en: Communications Chemistry, 2025, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42004-025-01553-8

ACS Medicinal Chemistry Letters

Autores: Katharina Scholz; Úrsula López-García; Romy Busch; Julian A. Marschner; Daniel Merk
Publicado en: ACS Medicinal Chemistry Letters, 2025, ISSN 1948-5875
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSMEDCHEMLETT.5C00572

Bidirectional optical control of osteogenesis with a light activated vitamin D mimetic

Autores: Xiu Ge; Sabine Willems; Francesco Melfi; Tufan Mukhopadhyay; Johannes Morstein; Jordan Artzy; Loris Knümann; Giorgia Sbriccoli; Jörg Pabel; Julian A. Marschner; Dirk Trauner; Daniel Merk
Publicado en: Crossref, 2025, ISSN 2573-2293
Editor: Various chemical societies
DOI: 10.26434/CHEMRXIV-2025-DDR0F

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Autores: Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A. Marschner, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editor: ACS
DOI: 10.1021/acs.jmedchem.3c00415

Exploring Fatty Acid Mimetics as NR4A Ligands

Autores: Tanja Stiller, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editor: ACS
DOI: 10.1021/acs.jmedchem.3c01467

Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole

Autores: Minh Sai, Jan Vietor, Moritz Kornmayer, Markus Egner, Úrsula López-García, Georg Höfner, Jörg Pabel, Julian A. Marschner, Thomas Wein, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editor: ACS
DOI: 10.1021/acs.jmedchem.3c00852

A Nurr1 Agonist Derived from the Natural Ligand DHI Induces Neuroprotective Gene Expression

Autores: Markus Egner, Romy Busch, Úrsula López-García, Max Lewandowski, Georg Höfner, Thomas Wein, Julian A. Marschner, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2025, ISSN 0022-2623
Editor: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c03104

Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools

Autores: Emily C. Hank, Minh Sai, Till Kasch, Isabelle Meijer, Julian A. Marschner, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, Edición 67, 2024, ISSN 0022-2623
Editor: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c01443

Bioactivity prediction with chemical language models trained on labeled molecules

Autores: Laura Isigkeit; Tim Hörmann; Vittorio Lembo; Johanna Ehrler; Ewgenij Proschak; Francesca Grisoni; Daniel Merk
Publicado en: Crossref, 2025, ISSN 2573-2293
Editor: Various chemical societies
DOI: 10.26434/CHEMRXIV-2025-LWNJS

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

Autores: Silvia Arifi, Julian A. Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser, Lennart Obeser, Georg Höfner, Ewgenij Proschak, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Publicado en: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c03417

Journal of Medicinal Chemistry

Autores: Tanja Stiller; Christian Gege; Wael Saeb; Jan Vietor; Úrsula López-García; Romy Busch; Hella Kohlhof; Daniel Vitt; Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2025, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/ACS.JMEDCHEM.5C01140

Automated design of multi-target ligands by generative deep learning

Autores: Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F. Lillich, Johanna H. M. Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A. Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-52060-8

Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing

Autores: Minh Sai, Emily C. Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A. Marschner, Daniel Merk
Publicado en: Communications Chemistry, Edición 7, 2024, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42004-024-01224-0

Chemogenomics for NR1 nuclear hormone receptors

Autores: Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Menge, Lewis Elson, Susanne Müller, Stefan Knapp,Alexandra Stolz, Julian Marschner, Daniel Merk
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.1038/s41467-024-49493-6

Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism

Autores: Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F. Lillich, Till Kasch, Úrsula López-García, Julian A. Marschner, Lorena A. Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, Edición 67, 2024, ISSN 0022-2623
Editor: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c01218

Comparative Profiling and Chemogenomics Application of Chemical Tools for NR4A Nuclear Receptors

Autores: Sabine Willems; Vasily Morozov; Julian A. Marschner; Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2025, ISSN 1520-4804
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.JMEDCHEM.5C00459

Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2

Autores: Max Lewandowski; Romy Busch; Julian A. Marschner; Daniel Merk
Publicado en: ACS Pharmacology & Translational Science, 2025, ISSN 2575-9108
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSPTSCI.4C00719

De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime

Autores: Marco Ballarotto, Sabine Willems, Tanja Stiller, Felix Nawa, Julian A. Marschner, Francesca Grisoni, Daniel Merk
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Editor: ACS
DOI: 10.1021/acs.jmedchem.3c00485

Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2

Autores: Max Lewandowski, Romy Busch, Julian A. Marschner, Daniel Merk
Publicado en: ACS Pharmacology & Translational Science, 2025, ISSN 2575-9108
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00719

Chemogenomics for steroid hormone receptors (NR3)

Autores: Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk
Publicado en: Communications Chemistry, Edición 8, 2025, ISSN 2399-3669
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01427-z