Probing (Orphan) Nuclear Receptors in Neurodegeneration

Project Information

NeuRoPROBE

Grant agreement ID: 101040355

DOI

10.3030/101040355

EC signature date 26 April 2022

Start date 1 May 2022

End date 30 April 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 498 813,00

EU contribution

€ 1 498 813,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Development of a Potent Nurr1 Agonist Tool for In Vivo Applications

Author(s): Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A. Marschner, Daniel Merk
Published in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Publisher: ACS
DOI: 10.1021/acs.jmedchem.3c00415

Exploring Fatty Acid Mimetics as NR4A Ligands

Author(s): Tanja Stiller, Daniel Merk
Published in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Publisher: ACS
DOI: 10.1021/acs.jmedchem.3c01467

Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole

Author(s): Minh Sai, Jan Vietor, Moritz Kornmayer, Markus Egner, Úrsula López-García, Georg Höfner, Jörg Pabel, Julian A. Marschner, Thomas Wein, Daniel Merk
Published in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Publisher: ACS
DOI: 10.1021/acs.jmedchem.3c00852

A Nurr1 Agonist Derived from the Natural Ligand DHI Induces Neuroprotective Gene Expression

Author(s): Markus Egner, Romy Busch, Úrsula López-García, Max Lewandowski, Georg Höfner, Thomas Wein, Julian A. Marschner, Daniel Merk
Published in: Journal of Medicinal Chemistry, 2025, ISSN 0022-2623
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c03104

Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools

Author(s): Emily C. Hank, Minh Sai, Till Kasch, Isabelle Meijer, Julian A. Marschner, Daniel Merk
Published in: Journal of Medicinal Chemistry, Issue 67, 2024, ISSN 0022-2623
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c01443

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

Author(s): Silvia Arifi, Julian A. Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser, Lennart Obeser, Georg Höfner, Ewgenij Proschak, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c03417

Automated design of multi-target ligands by generative deep learning

Author(s): Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F. Lillich, Johanna H. M. Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A. Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-52060-8

Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing

Author(s): Minh Sai, Emily C. Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A. Marschner, Daniel Merk
Published in: Communications Chemistry, Issue 7, 2024, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42004-024-01224-0

Chemogenomics for NR1 nuclear hormone receptors

Author(s): Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Menge, Lewis Elson, Susanne Müller, Stefan Knapp,Alexandra Stolz, Julian Marschner, Daniel Merk
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/s41467-024-49493-6

Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism

Author(s): Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F. Lillich, Till Kasch, Úrsula López-García, Julian A. Marschner, Lorena A. Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk
Published in: Journal of Medicinal Chemistry, Issue 67, 2024, ISSN 0022-2623
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.jmedchem.4c01218

De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime

Author(s): Marco Ballarotto, Sabine Willems, Tanja Stiller, Felix Nawa, Julian A. Marschner, Francesca Grisoni, Daniel Merk
Published in: Journal of Medicinal Chemistry, 2023, ISSN 1520-4804
Publisher: ACS
DOI: 10.1021/acs.jmedchem.3c00485

Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2

Author(s): Max Lewandowski, Romy Busch, Julian A. Marschner, Daniel Merk
Published in: ACS Pharmacology & Translational Science, 2025, ISSN 2575-9108
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00719

Chemogenomics for steroid hormone receptors (NR3)

Author(s): Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk
Published in: Communications Chemistry, Issue 8, 2025, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01427-z