A binary sensor with single-molecule digit to discriminate biofluids enclosing zero or at least one biomarker

Informations projet

NoOne

N° de convention de subvention: 101040383

DOI

10.3030/101040383

Date de signature de la CE 18 Mars 2022

Date de début 1 Avril 2022

Date de fin 31 Mars 2027

Financé au titre de

• European Research Council (ERC)

Coût total

€ 2 499 579,00

Contribution de l’UE

€ 2 499 579,00

Coordonné par

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy

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Publications

Peer reviewed articles (34)

Inside out: Exploring edible biocatalytic biosensors for health monitoring

Auteurs: Verdiana Marchianò, Angelo Tricase, Alessandra Cimino, Blanca Cassano, Michele Catacchio, Eleonora Macchia, Luisa Torsi, Paolo Bollella
Publié dans: Bioelectrochemistry, Numéro 161, 2025, ISSN 1567-5394
Éditeur: Elsevier BV
DOI: 10.1016/j.bioelechem.2024.108830

Long-term electrical characteristics of a poly-3-hexylthiophene water-gated thin-film tran-sistor

Auteurs: Luukkonen, A; Tewari, A; Björkström, K; Ghafari, AM; Macchia, E; Torricelli, F; Torsi, L; Österbacka, R.*
Publié dans: Organic Electronics, Numéro 120, 2023, ISSN 1566-1199
Éditeur: Elsevier BV
DOI: 10.1016/j.orgel.2023.106844

Implementation of Experimental Design Techniques to Optimize Immunoglobulins Detection with Ultrasensitive Sandwich Immunoassays

Auteurs: Cecilia Scandurra; Paolo Bollella; Ronald Österbacka; Francesco Leonetti; Eleonora Macchia; Luisa Torsi
Publié dans: Advanced Sensor Research, Numéro 1, 2022, ISSN 2751-1219
Éditeur: Wiley
DOI: 10.1002/adsr.202200009

Extended Work Function Shift of Large-Area Biofunctionalized Surfaces Triggered by a Few Single-Molecule Affinity Binding Events

Auteurs: Di Franco, C., Macchia, E., Sarcina, L., Ditaranto, N., Khaliq, A., Torsi, L.,* Scamarcio, G.
Publié dans: Advanced Interface Materials, Numéro 2201829, 2023, ISSN 2196-7350
Éditeur: WILEY
DOI: 10.1002/admi.202201829

Ultrasensitive detection of 2,4-dichlorophenoxyacetic acid by inhibiting alkaline phosphatase immobilized onto a highly porous gold nanocoral electrode

Auteurs: Angelo Tricase, Michele Catacchio, Verdiana Marchianò, Eleonora Macchia, Paolo Bollella, Luisa Torsi
Publié dans: Nanoscale, 2025, ISSN 2040-3364
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4nr04857a

Perspectives on systematic optimization of ultrasensitive biosensors through experimental design

Auteurs: Mariapia Caputo, Angelo Tricase, Verdiana Marchianò, Cecilia Scandurra, Matteo Piscitelli, Lucia Sarcina, Michele Catacchio, Cinzia Di Franco, Paolo Bollella, Luisa Torsi, Eleonora Macchia
Publié dans: Journal of Materials Chemistry C, Numéro 12, 2024, ISSN 2050-7526
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4tc02131b

Multistep Fabrication of OECTs via Direct Ink Writing, With Performance Analysis Based on a Novel Measurement Protocol

Auteurs: Amir Mohammad Ghafari; Oskar Backman; Emil Rosqvist; Chunlin Xu; Luisa Torsi; Eleonora Macchia; Ronald Österbacka
Publié dans: Advanced Electronic Materials, 2024, ISSN 2199-160X
Éditeur: Wiley
DOI: 10.1002/aelm.202400742

Rapid and Ultra‐Sensitive SARS‐CoV‐2 Subgenomic RNA Detection Using Single‐Molecule With a Large Transistor‐SiMoT Bioelectronic Platform

Auteurs: Eleonora Macchia, Anna Maria D'Erchia, Mariapia Caputo, Angelica Bianco, Claudia Leoni, Francesca Intranuovo, Cecilia Scandurra, Lucia Sarcina, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi, Graziano Pesole
Publié dans: Advanced Electronic Materials, 2025, ISSN 2199-160X
Éditeur: Wiley
DOI: 10.1002/aelm.202400908

Electric Field Cycling of Physisorbed Antibodies Reduces Biolayer Polarization Dispersion

Auteurs: Cinzia Di Franco, Eleonora Macchia, Michele Catacchio, Mariapia Caputo, Cecilia Scandurra, Lucia Sarcina, Paolo Bollella, Angelo Tricase, Massimo Innocenti, Riccardo Funari, Matteo Piscitelli, Gaetano Scamarcio, Luisa Torsi
Publié dans: Advanced Science, Numéro 12, 2025, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202412347

High voltage flexible glucose/O2 fully printed hydrogel-based enzymatic fuel cell.

Auteurs: Marchiano, V; Tricase, A; Ditaranto, N; Macchia, E; d'Ingeo, S; Di Franco, C; Scamar-cio, G; Torsi, L; Bollella, P.*
Publié dans: Journal Of Physics D-Applied Physics, Numéro 57 135503, 2024, ISSN 1361-6463
Éditeur: Purpose-Led Publishing
DOI: 10.1088/1361-6463/ad1850

Why a diffusing single-molecule can be detected in few minutes by a large capturing bioelectronic interface.

Auteurs: Macchia, E., De Caro, L., Torricelli, F., Di Franco, C., Mangiatordi, G.F., Scamarcio, G.*, and Torsi, L.*
Publié dans: Advanced Science, Numéro 9, 2022, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202104381

A Single-Molecule Bioelectronic Portable Array for Early Diagnosis of Pancreatic Cancer Precursors

Auteurs: Genco, E., Modena, F., Sarcina, L., Björkström, K., Brunetti, C., Caironi, M., Caputo, M., Demartis, V.M., Di Franco, C., Frusconi, G., Haeberle, L., Larizza, P., Mancini, M.T., Österbacka, R., Reeves, W., Scamarcio, G., Scandurra, C., Wheeler, M., Ca
Publié dans: Advanced Materials, Numéro 35, 2023, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/ADMA.202304102

A handheld intelligent single-molecule binary bioelectronic system for fast and reliable immunometric point-of-care testing

Auteurs: Macchia, E., Kovacs-Vajna, Z.M., Loconsole, D., Sarcina, L., Redolfi, M., Chironna, M., Torricelli, F., Torsi, L.
Publié dans: Science Advances, Numéro 27, 2022, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/SCIADV.ABO0881

Plasmonic Single‐Molecule Affinity Detection at 10⁻²⁰ Molar

Auteurs: Eleonora Macchia, Cinzia Di Franco, Cecilia Scandurra, Lucia Sarcina, Matteo Piscitelli, Michele Catacchio, Mariapia Caputo, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi
Publié dans: Advanced Materials, Numéro 37, 2025, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/adma.202418610

Tailoring Water-Based Graphite Conductive Ink Formulation for Enzyme Stencil-Printing: Experimental Design to Enhance Wearable Biosensor Performance

Auteurs: Marchianò, V., Tricase, A., Caputo, M., Farinini, E., Leardi, R., Imbriano, A., Leech, D., Kidayaveettil, R., Gentile, L., Torsi, L.*, Macchia, E.*, Bollella, P.*
Publié dans: Chemistry of Materials, Numéro 36, 2023, ISSN 0897-4756
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemmater.3c02229

Ultrasensitive and Highly Selective o-Phenylenediamine Molecularly Imprinted Polymer for the Detection of 2,4-Dichlorophenoxyacetic Acid

Auteurs: Angelo Tricase, Verdiana Marchianò, Eleonora Macchia, Nicoletta Ditaranto, Luisa Torsi, Paolo Bollella
Publié dans: Electrochimica Acta, Numéro 494, 2024, ISSN 0013-4686
Éditeur: Elsevier BV
DOI: 10.1016/j.electacta.2024.144430

β‐Sheets Orientation in Physisorbed Protein Layers

Auteurs: Matteo Piscitelli; Diellza Bajrami; Cinzia Di Franco; Lucia Sarcina; Michele Catacchio; Eleonora Macchia; Luisa Torsi; Boris Mizaikoff; Gaetano Scamarcio
Publié dans: Advanced Materials Interfaces, Numéro 12, 6, 2024, ISSN 2196-7350
Éditeur: WIELY
DOI: 10.1002/admi.202400867

A large‑area organic transistor with 3D‑printed sensing gate for noninvasive single‑molecule detection of pancreatic mucinous cyst markers

Auteurs: Sarcina, L., Viola, F., Modena, F., Picca, R.A., Bollella, P., Di Franco, C., Cioffi, N., Caironi, M., Österbacka, R., Esposito, I., Scamarcio, G., Torsi, L., Torricelli, F., Macchia, E.*
Publié dans: Analytical and Bioanalytical Chemistry, Numéro 414, 2022, ISSN 1618-2650
Éditeur: Springer
DOI: 10.1007/s00216-022-04040-4

Analysis of Clinical Samples of Pancreatic Cyst's Lesions with A Multi-Analyte Bioelectronic Simot Array Benchmarked Against Ultrasensitive Chemiluminescent Immunoassay

Auteurs: Scandurra, C., Björkström, K., Caputo, M., Sarcina, L., Genco, E., Modena, F., Viola, FA., Brunetti, C., Kovács-Vajna, Z.M., Di Franco, C., Haeberle, L., Larizza, P., Mancini, M.T., Österbacka, R., Reeves, W., Scamarcio, G., Wheeler, M., Caironi, M.,
Publié dans: Advanced Science, Numéro 2308141, 2024, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202308141

Stability of thiol-based self-assembled monolayer functionalized electrodes in EG-OFET-based applications.

Auteurs: Tewari, A., Björkström, K., Ghafari, A.M., Macchia, E., Torsi, L., Österbacka, R.*
Publié dans: FlatChem, Numéro 42, 2023, ISSN 2452-2627
Éditeur: Elsevier B.V.
DOI: 10.1016/J.FLATC.2023.100553

Single Molecule with a Large Transistor – SiMoT cytokine IL-6 Detection Benchmarked against a Chemiluminescent Ultrasensitive Immunoassay Array

Auteurs: Scandurra,C., Kim Björkström, K., Sarcina, L., Imbriano, A., Di Franco, C., Öster-backa, R., Bolella, P., Scamarcio, G., Torsi,L.,* Macchia, E
Publié dans: Advanced Materials Technologies,, Numéro 8, 2023, ISSN 2365-709X
Éditeur: Wiley
DOI: 10.1002/admt.202201910

Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers

Auteurs: Lucia Sarcina, Pietro Delre, Giovanni Graziano, Angela Stefanachi, Davide Blasi, Rosaria A. Picca, Cinzia Di Franco, Francesco Leonetti, Gaetano Scamarcio, Paolo Bollella, Giuseppe F. Mangiatordi,* Eleonora Macchia,* and Luisa Torsi*
Publié dans: Advanced Materials Interfaces, Numéro 10, 2023, ISSN 2196-7350
Éditeur: Wiley
DOI: 10.1002/admi.202300017

Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit

Auteurs: Macchia, Eleonora; Björkström, Kim; Tewari, Amit; Eskonen, Ville; Luukkonen, Axel; Ghafari, Amir Mohammad; Sarcina, Lucia; Caputo, Mariapia; Tong-Ochoa, Natalia; Kopra, Kari; Pettersson, Fredrik; Gounani, Zahra; Torsi, Luisa; Härmä, Harri; Österbacka, Ronald
Publié dans: Cell Reports Physical Science, Numéro 101874, 2024, ISSN 2666-3864
Éditeur: Cell Press
DOI: 10.1016/j.xcrp.2024.101874

Kelvin probe force microscopy on patterned large-area biofunctionalized surfaces: a reliable ultrasensitive platform for biomarker detection

Auteurs: Cinzia Di Franco; Matteo Piscitelli; Eleonora Macchia; Cecilia Scandurra; Michele Catacchio; Luisa Torsi; Gaetano Scamarcio
Publié dans: Journal of Materials Chemistry C, Numéro 1, 2023, ISSN 2050-7526
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d3tc03110a

Piercing the Shadows: Exploring the Influence of Signal Preprocessing on Interpreting Ultrasensitive Bioelectronic Sensor Data

Auteurs: Mariapia Caputo, Lucia Sarcina, Cecilia Scandurra, Michele Catacchio, Matteo Piscitelli, Cinzia Di Franco, Paolo Bollella, Gaetano Scamarcio, Luisa Torsi, Eleonora Macchia
Publié dans: ChemPlusChem, Numéro 90, 2025, ISSN 2192-6506
Éditeur: Wiley
DOI: 10.1002/cplu.202400520

Graphene‐Based Opto‐Electronic Platform for Ultra‐Sensitive Biomarker Detection at Zeptomolar Concentrations

Auteurs: Matteo Piscitelli; Cinzia Di Franco; Giuseppe Valerio Bianco; Giovanni Bruno; Eleonora Macchia; Luisa Torsi; Gaetano Scamarcio
Publié dans: Small Methods, 2025, ISSN 2366-9608
Éditeur: WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.202402026

Chemical Reviews

Auteurs: Macchia, E., Torricelli, F., Bollella, P., Sarcina, L., Tricase, A., Di Franco, C., Österbacka, R., Kovács-Vajna, Z.M., Scamarcio, G., Torsi, L.*
Publié dans: Chemical Reviews, Numéro 122, 2022, ISSN 0009-2665
Éditeur: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00290

Water-Based Conductive Ink Formulations for Enzyme-Based Wearable Biosensors

Auteurs: Tricase, A., Imbriano, A., Valentino, M., Ditaranto, N., Macchia, E., Di Franco, C., Kidayaveettil, R., Leech, D., Piscitelli, M., Scamarcio, G., Perchiazzi, G., Torsi, L.* Paolo Bollella, P.
Publié dans: Advanced Sensor Research, Numéro 3, 2023, ISSN 2751-1219
Éditeur: Wiley
DOI: 10.1002/adsr.202300036

A stable physisorbed layer of packed capture antibodies for high-performance sensing applications

Auteurs: Sarcina, L., Scandurra, C., Di Franco, C., Caputo, M., Catacchio, M., Bollella, P., Scamarcio, G., Macchia, E., Torsi, L.*
Publié dans: Journal of Materials Chemistry C, Numéro 11, 2023, ISSN 2050-7526
Éditeur: The Royal Society of Chemistry
DOI: 10.1039/D3TC01123B

Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection

Auteurs: Eleonora Macchia, Fabrizio Torricelli, Paolo Bollella, Lucia Sarcina, Angelo Tricase, Cinzia Di Franco, Ronald Österbacka, Zsolt M. Kovács-Vajna, Gaetano Scamarcio, Luisa Torsi
Publié dans: Chemical Reviews, Numéro 122, 2023, ISSN 0009-2665
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMREV.1C00290

Self-powered wearable biosensor based on stencil-printed carbon nanotube electrodes for ethanol detection in sweat

Auteurs: Verdiana Marchianò; Angelo Tricase; Eleonora Macchia; Paolo Bollella; Luisa Torsi
Publié dans: Analytical and Bioanalytical Chemistry, Numéro 416, 2024, ISSN 1618-2650
Éditeur: Springer
DOI: 10.1007/S00216-024-05467-7

Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap

Auteurs: Sarcina, L.; Macchia,*E; Loconsole, G.; D’Attoma, G.; Bollella, P.; Catacchio M.; Leo-netti, F.; Di Franco, C.; Elicio, V.; Scamarcio, G.; Palazzo, G.; Boscia, D.; Saldarelli, S.; and Torsi, L
Publié dans: Advanced Science 2022, Numéro 2203900, 2022, ISSN 2198-3844
Éditeur: WILEY
DOI: 10.1002/advs.202203900

Point-Of-Care Ultra-Portable Single-Molecule Bioassays for One-Health

Auteurs: Macchia, E., Torricelli, F., Caputo, M., Sarcina, L., Scandurra, C., Bollella, P., Catac-chio, M., Piscitelli, M., Di Franco, C., Scamarcio, G., Torsi, L.
Publié dans: Advanced Materials, Numéro VOL 36 (13), 2023, ISSN 1521-4095
Éditeur: WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202309705

Experimental design of stencil-printed high-performance organic electrochemical transistors

Auteurs: Amir Mohammad Ghafari; Michele Catacchio; Emil Rosqvist; Axel Luukkonen; Anni Eklund; Kim Björkström; Paolo Bollella; Luisa Torsi; Eleonora Macchia; Ronald Österbacka
Publié dans: Advanced Materials, Numéro 4, 2023, ISSN 2633-5409
Éditeur: The Royal Society of Chemistry
DOI: 10.1039/d3ma00888f

Conference proceedings (3)

Physical Modelling of Large-Area Single-Molecule Organic Transistors

Auteurs: Fabrizio Torricelli, Eleonora Macchia, Paolo Bollella, Cinzia Di Franco, Zsolt M. Kovacs-Vajna, Gaetano Scamarcio, Luisa Torsi
Publié dans: 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS), 2022
Éditeur: IEEE
DOI: 10.1109/FLEPS53764.2022.9781507

Large-area bio-electronic sensors for early detection of pancreatic-biliary cancer protein markers

Auteurs: Lucia Sarcina, Fabrizio Viola, Francesco Modena, Paolo Bollella, Mario Caironi, Irene Esposito, Luisa Torsi, Fabrizio Torricelli, Eleonora Macchia
Publié dans: 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS), 2022
Éditeur: IEEE
DOI: 10.1109/FLEPS53764.2022.9781550

Flexible Carbon-based electrodes for amperometric biosensor development

Auteurs: Angelo Tricase, Verdiana Marchianò, Eleonora Macchia, Reshma Kidayaveettil, Donal Leech, Gaetano Scamarcio, Gaetano Perchiazzi, Luisa Torsi, Paolo Bollella
Publié dans: 2024 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS), 2024
Éditeur: IEEE
DOI: 10.1109/FLEPS61194.2024.10603574