Project description
Toward a large-scale, implantable, and wireless neuroprosthesis to treat memory deficit
Learning and remembering are fundamental cognitive tasks that enhance a person’s overall quality of life. Deficits impact social interactions, employment and activities of daily living and incur anxiety and depression in many cases. The hippocampus-prefrontal cortex circuit and large-scale oscillations in electrical activity here are essential for learning and memory. The ambitious ERC-funded MEMOPROSTHETICS project plans to create a large-scale neuroprosthesis of the hippocampus-prefrontal cortex circuit to improve learning and memory for patients with deficits. A novel brain implant in non-human primates performing a visuospatial learning task will enable development of specific stimulation protocols. The platform will be converted to a fully implantable and wireless neuroprosthesis.
Objective
Cognitive deficits caused by ageing, neurodegenerative diseases or brain injury represent a major public health issue. They are associated with a disruption of neural oscillations in large-scale brain networks, which cannot be restored using current treatments. Here, I propose a new neuromodulation framework for manipulating neural oscillations across large-scale brain networks to improve learning and memory. Specifically, I will create a large-scale neuroprosthesis of the hippocampus-prefrontal cortex circuit, which will simultaneously record and stimulate electrically key areas of the episodic memory network. I hypothesize that spatially, spectrally and temporally specific stimulation protocols within this network will enhance the functional interactions between hippocampus and prefrontal cortex, and will improve learning and memory. This conceptual approach will be evaluated in non-human primates trained on a visuospatial learning task.
First, I will combine an electrocorticographic grid over the prefrontal cortex with depth macroelectrodes in the hippocampus and entorhinal cortex to create a novel large-scale brain implant. I will use this device to investigate the neural signatures of successful vs failed trials. Next, I will optimize electrical stimulation protocols that replicate successful neural signatures, and will test whether they improve memory in healthy animals. Third, I will induce temporary cognitive deficits in the animals using a cholinergic antagonist, and will assess the effects of stimulation in this pharmacological model of dementia. Finally, I will evaluate the chronic feasibility of this approach by translating these concepts into a fully implantable and wireless platform suited for future clinical applications. MEMOPROSTHETICS will lead to the development of neuroprostheses that palliate memory deficits in preclinical models of ageing and dementia, and will open new avenues for studying and treating a wide range of cognitive impairments.
Fields of science
Not validated
Not validated
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-AG - HORIZON Action Grant Budget-BasedHost institution
75794 Paris
France