Project description
Improved understanding of diabetic kidney disease
One of the main complications of diabetes is diabetic kidney disease (DKD), which in 20 % of the cases will progress to kidney failure. Patients with DKD present with complex and variable pathophysiology, suggesting that a personalised approach to treatment is needed. The limited therapy options available to date have driven scientists of the DECODE-DKD project, funded by the European Research Council, to study DKD pathophysiology and identify new drug targets. Researchers will employ a multi-omics approach to identify disease relevant pathways and provide detailed knowledge on the mechanisms. Moreover, the project will develop patient in vitro kidney organoids to screen various candidate compounds.
Objective
Diabetic kidney disease (DKD) is a rapidly growing worldwide health problem and represents one of the most serious threats in current medicine. DKD is the most common cause of chronic kidney disease (CKD) with 20% of DKD patients progressing to end-stage renal disease, which is associated with tremendously increased morbidity and mortality. The pathophysiology of DKD is complex, incompletely understood and the number of treatment options is low. The vision of DECODE-DKD is to utilize a patient-centric research approach to identify novel pathways and druggable targets in patients suffering from DKD. Concrete objectives are: (1) to establish a spatially resolved multi-omic landscape of human DKD; (2) to dissect and identify therapeutic pathways and signalling networks for novel drug target identification; (3) to incorporate patient-derived in-vitro models for target validation. It is envisaged that novel spatial and single-cell multi-omic technologies will generate a blueprint and predictive model of DKD. This unbiased map will serve to generate testable hypotheses with spatial and temporal coordinates at single-cell resolution. To identify disease-relevant pathways and novel drugable targets in-vitro and in-vivo genome editing approaches will be employed combined with high-throughput screens. In-vitro assays with human-derived kidney organoids will be used to screen potential compounds facilitating the development of novel therapeutics. This highly ambitious interdisciplinary proposal requires the expertise of biomedical engineers, computational biologists, biomedical researchers and physician-scientists. The generated knowledge and outcomes of DECODE-DKD will - alone and especially together - be truly transformative and provide an incremental step forward towards novel drug targets and precision medicine for the treatment of diabetic kidney disease using a systems medicine approach.
Fields of science
Not validated
Not validated
- medical and health sciencesclinical medicineendocrinologydiabetesdiabetic nephropathy
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesclinical medicinenephrologykidney diseases
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-AG - HORIZON Action Grant Budget-BasedHost institution
52074 Aachen
Germany