Descrizione del progetto
Migliore comprensione della nefropatia diabetica
Una delle principali complicanze del diabete è la nefropatia diabetica (DKD, Diabetic Kidney Disease), che nel 20 % dei casi progredisce fino all’insufficienza renale. I pazienti affetti da DKD presentano una fisiopatologia complessa e variabile, il che suggerisce la necessità di un approccio personalizzato al trattamento. Le limitate opzioni terapeutiche finora disponibili hanno spinto gli scienziati del progetto DECODE-DKD, finanziato dal Consiglio europeo della ricerca, a studiare la fisiopatologia della nefropatia diabetica e a identificare nuovi bersagli farmacologici. I ricercatori utilizzeranno un approccio multi-omico per identificare i percorsi rilevanti per la malattia e fornire conoscenze dettagliate sui meccanismi. Inoltre, il progetto prevede lo sviluppo di organoidi renali in vitro di pazienti per lo screening di vari composti candidati.
Obiettivo
Diabetic kidney disease (DKD) is a rapidly growing worldwide health problem and represents one of the most serious threats in current medicine. DKD is the most common cause of chronic kidney disease (CKD) with 20% of DKD patients progressing to end-stage renal disease, which is associated with tremendously increased morbidity and mortality. The pathophysiology of DKD is complex, incompletely understood and the number of treatment options is low. The vision of DECODE-DKD is to utilize a patient-centric research approach to identify novel pathways and druggable targets in patients suffering from DKD. Concrete objectives are: (1) to establish a spatially resolved multi-omic landscape of human DKD; (2) to dissect and identify therapeutic pathways and signalling networks for novel drug target identification; (3) to incorporate patient-derived in-vitro models for target validation. It is envisaged that novel spatial and single-cell multi-omic technologies will generate a blueprint and predictive model of DKD. This unbiased map will serve to generate testable hypotheses with spatial and temporal coordinates at single-cell resolution. To identify disease-relevant pathways and novel drugable targets in-vitro and in-vivo genome editing approaches will be employed combined with high-throughput screens. In-vitro assays with human-derived kidney organoids will be used to screen potential compounds facilitating the development of novel therapeutics. This highly ambitious interdisciplinary proposal requires the expertise of biomedical engineers, computational biologists, biomedical researchers and physician-scientists. The generated knowledge and outcomes of DECODE-DKD will - alone and especially together - be truly transformative and provide an incremental step forward towards novel drug targets and precision medicine for the treatment of diabetic kidney disease using a systems medicine approach.
Campo scientifico
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.
- medical and health sciencesclinical medicineendocrinologydiabetesdiabetic nephropathy
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesclinical medicinenephrologykidney diseases
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
HORIZON-AG - HORIZON Action Grant Budget-BasedIstituzione ospitante
52074 Aachen
Germania