New class of RNA caps and their role in cellular response to infection and stress
The EU-funded StressRNaction project is investigating the role of newly discovered non-canonical RNA caps, dinucleoside polyphosphates (NpnNs), in prokaryotes and eukaryotes. These 5' termini specially altered nucleotides, or caps, are vital for the creation of mature messenger RNA and for translation during protein synthesis. The methylated NpnN caps discovered by project researchers stabilise RNA in Escherichia coli in the stationary phase and can be found in mammalian cells. The objective is to develop selective capturing techniques to identify NpnN–RNA sequences and the interacting partners. The project aims to understand the metabolism of NpnN caps, their role in the immune response to viruses and bacteria, and stress conditions in prokaryotic and eukaryotic cells.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Call for proposalSee other projects for this call
Funding SchemeHORIZON-AG - HORIZON Action Grant Budget-Based
16610 Praha 6
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