BiFoldome: Homo- and Hetero-typic Interactions in Assembled Foldomes

Project Information

BiFOLDOME

Grant agreement ID: 101042403

DOI

10.3030/101042403

EC signature date 25 August 2022

Start date 1 November 2022

End date 31 October 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 496 823,00

EU contribution

€ 1 496 823,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

NMR characterization of an assembling RHIM (RIP homotypic interaction motif) amyloid reveals a cryptic region for self-recognition

Author(s): Chi L.L. Pham; Gustavo A. Titaux-Delgado; Nikhil R. Varghese; Paula Polonio; Karyn L. Wilde; Margaret Sunde; Miguel Mompeán
Published in: Journal of Biological Chemistry, 2023, ISSN 1083-351X
Publisher: American Society for Biochemistry and Molecular Biology
DOI: 10.5281/zenodo.10646172

Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1

Author(s): Paula Polonio, Jorge Pedro López-Alonso, Hanxing Jiang, Sara Andrés-Campos, Fátima C. Escobedo-González, Gustavo A. Titaux-Delgado, Iban Ubarretxena-Belandia, Miguel Mompeán
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64621-6

Solution NMR reveals micelle-stabilized α-helical segments flanking the RIPK1 RHIM amyloid core

Author(s): Paula Polonio, Gustavo A. Titaux-Delgado, Miguel Mompeán
Published in: Biochemical and Biophysical Research Communications, Issue 809, 2026, ISSN 0006-291X
Publisher: Elsevier BV
DOI: 10.1016/J.BBRC.2026.153513

3D-printed device for efficient packing of semisolid samples in 3.2 mm rotors used in cryoprobe systems

Author(s): Andrea Gelardo; Gustavo A. Titaux-Delgado
Published in: Magnetic Resonance in Chemistry, 2025, ISSN 0749-1581
Publisher: Wiley
DOI: 10.1002/mrc.70010

Hydrogen bonding patterns and cooperativity in polyproline II helical bundles

Author(s): Rubén López-Sánchez; Douglas V. Laurents; Miguel Mompeán
Published in: Communications Chemistry, 2024, ISSN 2399-3669
Publisher: Springer Nature
DOI: 10.1038/S42004-024-01268-2

<scp>PolyProline</scp> Predictor: A web server for empirical sequence‐based prediction of polyproline <scp>II</scp> helices

Author(s): Rubén López‐Sánchez, David Pantoja‐Uceda, Miguel Mompeán, Douglas V. Laurents
Published in: Protein Science, Issue 35, 2026, ISSN 0961-8368
Publisher: Wiley
DOI: 10.1002/PRO.70675

Membrane charge primes the necroptotic kinase RIPK3 for amyloid assembly

Author(s): Fátima C. Escobedo-González, Andrea Gelardo, Alexandra Reimers, Paula Polonio, Miguel Mompeán, Gustavo A. Titaux-Delgado
Published in: Communications Chemistry, Issue 8, 2025, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42004-025-01658-0

Resonance assignments of the human receptor interacting protein kinase 1 (RIPK1) in its fibrillar conformation

Author(s): Paula Polonio, Miguel Mompeán
Published in: Biomolecular NMR Assignments, Issue 19, 2025, ISSN 1874-2718
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S12104-025-10249-Y

High-quality 13C-detected structural analysis of mass-limited amyloid samples using a CPMAS CryoProbe and moderate magnetic fields

Author(s): Sara Andrés-Campos, Gustavo A. Titaux-Delgado, Fátima C. Escobedo-González, Miguel Mompeán
Published in: Solid State Nuclear Magnetic Resonance, Issue 139, 2026, ISSN 0926-2040
Publisher: Elsevier BV
DOI: 10.1016/J.SSNMR.2025.102028

Charged membrane interfaces reshape the nucleation landscape of RIPK3 amyloid variants

Author(s): Fátima C. Escobedo-González, Andrea Gelardo, Gustavo A. Titaux-Delgado, Miguel Mompeán
Published in: European Biophysics Journal, Issue 55, 2026, ISSN 0175-7571
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00249-026-01833-8

SARS-CoV-2 Nsp8 N-terminal domain folds autonomously and binds dsRNA

Author(s): Miguel Á Treviño; David Pantoja-Uceda; Douglas V Laurents; Miguel Mompeán
Published in: Nucleic Acids Research, 2023, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.5281/zenodo.10646152

Orientation affects hydrogen bonding cooperativity in polyproline II helical bundles

Author(s): Rubén López-Sánchez, Miguel Mompeán, Douglas V. Laurents
Published in: Communications Chemistry, Issue 8, 2025, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42004-025-01576-1