Objective
Deciphering the code of life has sparked one of the biggest scientific endeavours in human history. Today, 18 years after the completion of the Human Genome Project, databases around the globe host over a million genomes. Surprisingly, one of the most important results that has emerged from this abundance of genetic information is how diverse and complex the processes are that control the constant regeneration, preservation, and adaptation of life. Understanding the relationships between cellular genotype and phenotype is therefore of fundamental importance in developmental biology as well as in the biomedical sciences.
Many molecular mechanisms that shape our body during our life are still largely un-known due to the limitations of current sequencing technologies which can only glimpse a single moment in time. In stark contrast, biological cells constantly monitor their function and can, if needed, quickly adjust to changes in their environment by the transfer of information between the nucleus and the cellular protein machinery in form of RNA. Yet despite their essential function no technique can record these highly dynamic profiles of intracellular RNA. Gathering transcriptomic profiles from intact cells and within living organisms therefore represents a major challenge for any existing sequencing and sensing technology.
Here, HYPERION introduces an entirely new concept of optical sequencing to detect transcriptomic information in real time and inside living biological cells. It is based on ultra-sensitive plasmonic nanolasers that combine recent advancements in extreme optics with a new concept to spatially confine RNA molecules. These lasers could be adapted to sense other biomolecules and mark the beginning of a new era in intracellular biosensing. Like the titan god of light, supposed to bring mankind the gift of sight, HYPERION will exploit the unrivalled precision of laser light to uncover the processes that shape life on the molecular level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics genomes
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
50931 KOLN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.