Objective
EXPOMET proposes a pioneering mass spectrometry-based platform for omic-scale assessment of chemical exposures. EXPOMET will revolutionize our perception of environmental contaminants and the influence these have on breast cancer (BC).
In our ageing society, the incidence of chronic disease is constantly rising; yet, environmental drivers of disease susceptibility are poorly understood. Measuring the myriad of chemicals that humans are constantly exposed to is immensely challenging; and identifying interactions and the molecular pathways that are disrupted is an even more complex task. To address this issue, the concept of the exposome, i.e. the totality of chemical exposures and the biological effects thereof, was proposed. Innovative analytical technology, however, is lacking and remains the major limitation in this emerging field.
EXPOMET aims to establish new avenues towards a comprehensive sequencing of the exposome and illuminating the role played in the etiology of BC. Affecting 1 in 8, BC is the most common cancer in European women. Novel workflows will overcome current limitations and enable high-throughput exposure and effect monitoring of a vast number of environmentally-relevant chemicals. The developed cutting-edge methods will be applied, and critically evaluated, in the first exposome-wide association (ExWAS) study on BC. A deeper understanding of the toxicological impact of co-exposure will be obtained from ensuing functional, systems-level experiments. Breakthrough metabolomic-guided pathway mapping and activity-screening technology will be utilized for investigating causative events.
The project will provide unique insights into the impact of chemical exposure on the etiology of BC and ground-breaking exposomic technology. EXPOMET will revolutionize viewpoints on environmental contaminants and the influence these have on chronic disease. The PI has a uniquely interdisciplinary expertise to address the multi-facets of this exposome approach.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1010 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.