Identification of novel diagnostic, predictive and therapeutic strategies in chronic kidney disease

Project Information

TargetCKD

Grant agreement ID: 101043403

DOI

10.3030/101043403

EC signature date 23 June 2022

Start date 1 July 2022

End date 30 June 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 063,00

EU contribution

€ 1 999 063,00

Coordinated by

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Trends in Cell Biology

Author(s): E. Dilmen; I. Orhon; J. Jansen; J.G.J. Hoenderop
Published in: Trends in Cell Biology, 2024, ISSN 1879-3088
Publisher: Elsevier
DOI: 10.1016/J.TCB.2023.09.005

Mapping cardiac remodeling in chronic kidney disease

Author(s): Kaesler, Nadine; Cheng, Mingbo; Nagai, James; O’Sullivan, James; Peisker, Fabian; Bindels, Eric M. J.; Babler, Anne; Moellmann, Julia; Droste, Patrick; Franciosa, Giulia; Dugourd, Aurelien; Saez-Rodriguez, Julio; Neuss, Sabine; Lehrke, Michael; Boor, Peter; Goettsch, Claudia; Olsen, Jesper V.; Speer, Thimoteus; Lu, Tzong-Shi; Lim, Kenneth; Floege, Jürgen; Denby, Laura; Costa, Ivan; Kramann, Rafael
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.18154/rwth-conv-252253

Abstracts zum 131. Kongress der Deutschen Gesellschaft für Innere Medizin e.V.

Published in: Die Innere Medizin, 2025, ISSN 2731-7099
Publisher: Springer Medizin Verlag
DOI: 10.1007/S00108-025-01898-1

Nature

Author(s): Christoph Kuppe; Ricardo O. Ramirez Flores; Zhijian Li; Sikander Hayat; Rebecca T. Levinson; Xian Liao; Monica T. Hannani; Jovan Tanevski; Florian Wünnemann; James S. Nagai; Maurice Halder; David Schumacher; Sylvia Menzel; Gideon Schäfer; Konrad Hoeft; Mingbo Cheng; Susanne Ziegler; Xiaoting Zhang; Fabian Peisker; Nadine Kaesler; Turgay Saritas; Yaoxian Xu; Astrid Kassner; Jan Gummert; Michiel Morshuis; Junedh Amrute; Rogier J. A. Veltrop; Peter Boor; Karin Klingel; Linda W. Van Laake; Aryan Vink; Remco M. Hoogenboezem; Eric M. J. Bindels; Leon Schurgers; Susanne Sattler; Denis Schapiro; Rebekka K. Schneider; Kory Lavine; Hendrik Milting; Ivan G. Costa; Julio Saez-Rodriguez; Rafael Kramann
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05060-x

Nature Communications

Author(s): Konrad Hoeft; Tore Bleckwehl; David Schumacher; Hyojin Kim; Robert Meyer; Qingqing Long; Ling Zhang; Christian Möller; Marian C. Clahsen-van Groningen; Anne Babler; Turgay Saritas; Ingo Kurth; Hendrik Milting; Sikander Hayat; Rafael Kramann
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.18154/RWTH-2024-11810

Protocol to analyze bioenergetics in single human induced-pluripotent-stem-cell-derived kidney organoids using Seahorse XF96

Author(s): Verónica Miguel; Katharina Charlotte Reimer; Anna Katharina Galyga; Jitske Jansen; Julia Möllmann; Luisa Meyer; Rebekka K. Schneider; Rafael Kramann
Published in: STAR Protocols, Vol 4, Iss 1, Pp 101999- (2023), 2023, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.18154/rwth-conv-252258

Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis

Author(s): Tore Bleckwehl; Anne Babler; Merel Tebens; Sidrah Maryam; Michael Nyberg; Markus Bosteen; Maurice Halder; Isaac Shaw; Susanne Fleig; Charles Pyke; Henning Hvid; Louise Marie Voetmann; Jaap D. van Buul; Judith C. Sluimer; Vivek Das; Simon Baumgart; Rafael Kramann; Sikander Hayat
Published in: Nature Cardiovascular Research, 2024, ISSN 2731-0590
Publisher: Nature
DOI: 10.1038/S44161-024-00582-1

ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts

Author(s): Konrad Hoeft; Lars Koch; Susanne Ziegler; Ling Zhang; Steffen Luetke; Maria C. Tanzer; Debashish Mohanta; David Schumacher; Felix Schreibing; Qingqing Long; Hyojin Kim; Barbara M. Klinkhammer; Carla Schikarski; Sidrah Maryam; Mathijs Baens; Juliane Hermann; Sarah Krieg; Fabian Peisker; Laura De Laporte; Gideon J.L. Schaefer; Sylvia Menzel; Joachim Jankowski; Benjamin D. Humphreys; Adam Wahida; Rebekka K. Schneider; Matthias Versele; Peter Boor; Matthias Mann; Gerhard Sengle; Sikander Hayat; Rafael Kramann
Published in: Journal of Clinical Investigation, 2024, ISSN 1558-8238
Publisher: American society for clinical investigation
DOI: 10.1172/JCI170246

Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis

Author(s): Lars Koch; Konrad Hoeft; Rafael Kramann
Published in: Signal Transduction and Targeted Therapy, 2025, ISSN 2059-3635
Publisher: Nature
DOI: 10.18154/RWTH-2025-01640

IgA nephropathy

Author(s): Eleni Stamellou; Claudia Seikrit; Sydney C. W. Tang; Peter Boor; Vladimir Tesař; Jürgen Floege; Jonathan Barratt; Rafael Kramann
Published in: Nature Reviews Disease Primers, 2023, ISSN 2056-676X
Publisher: Nature Publishing Group
DOI: 10.1038/s41572-023-00476-9

Nature Genetics

Author(s): Yaoxian Xu; Christoph Kuppe; Javier Perales-Patón; Sikander Hayat; Jennifer Kranz; Ali T. Abdallah; James Nagai; Zhijian Li; Fabian Peisker; Turgay Saritas; Maurice Halder; Sylvia Menzel; Konrad Hoeft; Annegien Kenter; Hyojin Kim; Claudia R. C. van Roeyen; Michael Lehrke; Julia Moellmann; Thimoteus Speer; Eva M. Buhl; Remco Hoogenboezem; Peter Boor; Jitske Jansen; Cordula Knopp; Ingo Kurth; Bart Smeets; Eric Bindels; Marlies E. J. Reinders; Carla Baan; Joost Gribnau; Ewout J. Hoorn; Joachim Steffens; Tobias B. Huber; Ivan Costa; Jürgen Floege; Rebekka K. Schneider; Julio Saez-Rodriguez; Benjamin S. Freedman; Rafael Kramann
Published in: Nature Genetics, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01202-z

Mapping Human Cardiac Sarcoidosis by Single Nuclear and Spatial Profiling

Author(s): Sikander Hayat; Rafael Kramann
Published in: urn:issn:0009-7330, 2022, ISSN 1524-4571
Publisher: American Heart Association Journals
DOI: 10.1161/circresaha.122.321778

Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

Author(s): Hoeft, Konrad; Schaefer, Gideon J. L.; Kim, Hyojin; Schumacher, David; Bleckwehl, Tore; Long, Qingqing; Klinkhammer, Barbara Mara; Peisker, Fabian; Koch, Lars; Nagai, James S.; Halder, Maurice; Ziegler, Susanne; Liehn, Elisa; Kuppe, Christoph; Kranz, Jennifer; Menzel, Sylvia; Costa, Ivan G.; Wahida, Adam; Boor, Peter; Schneider, Rebekka K.; Hayat, Sikander; Kramann, Rafael
Published in: Cell reports 42(2), 112131 (2023). doi:10.1016/j.celrep.2023.112131, 2023, ISSN 2639-1856
Publisher: Cell Press
DOI: 10.18154/rwth-2023-07750