dAta-dRiven integrated approaches to CHemIcal safety assessMEnt and Drug dEvelopment

Project Information

ARCHIMEDES

Grant agreement ID: 101043848

DOI 10.3030/101043848

EC signature date 3 June 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Data Management Plan

Publications

Peer reviewed articles (11)

A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes

Author(s): Giusy del Giudice; Angela Serra; Alisa Pavel; Marcella Torres Maia; Laura Aliisa Saarimäki; Michele Fratello; Antonio Federico; Harri Alenius; Bengt Fadeel; Dario Greco
Published in: Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024), 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1101/2024.01.06.574295

Human Genomics

Author(s): Antonio Federico; Alisa Pavel; Lena Möbus; David McKean; Giusy del Giudice; Vittorio Fortino; Hanna Niehues; Joe Rastrick; Kilian Eyerich; Stefanie Eyerich; Ellen van den Bogaard; Catherine Smith; Stephan Weidinger; Emanuele de Rinaldis; Dario Greco
Published in: Human Genomics, 2021, ISSN 1473-9542
Publisher: BMC
DOI: 10.1101/2021.05.10.443441

The potential of a data centred approach & knowledge graph data representation in chemical safety and drug design

Author(s): Pavel, Alisa; Saarimäki, Laura A; Möbus, Lena; Federico, Antonio; Serra, Angela; Greco, Dario
Published in: Computational and Structural Biotechnology Journal, 2022, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2022.08.061

Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach

Author(s): Saarimäki, Laura Aliisa; Morikka, Jack; Pavel, Alisa; Korpilähde, Seela; del Giudice, Giusy; Federico, Antonio; Fratello, Michele; Serra, Angela; Greco, Dario
Published in: Advanced Science, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202203984

A Multi‐Dimensional Approach to Map Disease Relationships Challenges Classical Disease Views

Author(s): Lena Möbus; Angela Serra; Michele Fratello; Alisa Pavel; Antonio Federico; Dario Greco
Published in: Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024), 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202401754

Journal of Translational Medicine

Author(s): Antonio Federico; Lena Möbus; Zeyad Al-Abdulraheem; Alisa Pavel; Vittorio Fortino; Giusy del Giudice; Harri Alenius; Nanna Fyhrquist; Dario Greco
Published in: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024), 2023, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-024-04879-4

KNeMAP: a network mapping approach for knowledge-driven comparison of transcriptomic profiles

Author(s): Alisa Pavel; Giusy del Giudice; Michele Fratello; Leo Ghemtio; Antonio Di Lieto; Jari Yli-Kauhaluoma; Henri Xhaard; Antonio Federico; Angela Serra; Dario Greco
Published in: Bioinformatics, 2023, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btad341

A curated gene and biological system annotation of adverse outcome pathways related to human health

Author(s): Laura Aliisa Saarimäki; Michele Fratello; Alisa Pavel; Seela Korpilähde; Jenni Leppänen; Angela Serra; Dario Greco
Published in: Scientific Data, 2023, ISSN 2052-4463
Publisher: Springer
DOI: 10.1038/s41597-023-02321-w

The in vitro immunomodulatory effect of multi-walled carbon nanotubes by multilayer analysis

Author(s): Hautanen, Veera; Morikka, Jack; Saarimäki, Laura Aliisa; Bisenberger, Jan; Toimela, Tarja; Serra, Angela; Greco, Dario
Published in: NanoImpact, 2023, ISSN 2452-0748
Publisher: Science direct
DOI: 10.1016/j.impact.2023.100476

Expanding adverse outcome pathways towards one health models for nanosafety

Author(s): Laura Aliisa Saarimäki; Laura Aliisa Saarimäki; Giusy del Giudice; Giusy del Giudice; Dario Greco; Dario Greco; Dario Greco
Published in: Frontiers in Toxicology, Vol 5 (2023), 2023, ISSN 2673-3080
Publisher: Frontiers
DOI: 10.3389/ftox.2023.1176745

Nature Nanotechnology

Author(s): del Giudice G, Serra A, Saarimäki LA, Kotsis K, Rouse I, Colibaba SA, Jagiello K, Mikolajczyk A, Fratello M, Papadiamantis AG, Sanabria N, Annala ME, Morikka J, Kinaret PAS, Voyiatzis E, Melagraki G, Afantitis A, Tämm K, Puzyn T, Gulumian M, Lobaskin V,
Published in: Nature Nanotechnology, Issue 18, 957–966 (2023), 2023, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/S41565-023-01393-4

Thesis and dissertations (1)

Knowledge Graphs, Network Models and Health Data Science Approaches for Toxicology and Pharmacology

Author(s): Pavel, Alisa
Published in: 2024
Publisher: Tampere University