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The evolution of neural circuits for navigational decisions - from synapses to behavior

Objective

Of the 1.2 million animal species described on Earth, more than 80% are insects. As for mammals, each insect is equipped with a brain that has evolved to optimally control the species’ behavior in the context of its environment. In more than 450 million years of evolution the neural circuits guiding behavioral decisions have diverged from an ancestral version to enable insects to conquer every terrestrial habitat on the planet and to equip many species with behavioral strategies that rival even mammals in complexity. These circuits thus have to be rigid enough to maintain their ancestral, core functions, while also being sufficiently adaptable to enable the addition of novel functions. The mechanisms of how this is achieved across vast evolutionary timescales are unknown. While this is true for all animals, insects with their numerically simpler brains and a comparably rigid neuroarchitecture offer the unique chance to unravel the evolution of decision making circuits at the level of identified neurons and synapses. Aided by recent technological breakthroughs and the establishment of rich ground-truth data in the fruit fly, I will combine whole brain anatomy, connectomics and computational modeling with electrophysiology and behavior to dissect the evolution of the central decision making center of insect brains, the central complex - across the entire insect phylogeny. I aim to reveal how this region has evolved in the context of the entire brain, how its intrinsic circuits have changed with increasing evolutionary distance (circuit phylogeny), and which changes in its circuitry are linked to specialized behavioral abilities (circuit adaptation). Finally, I will directly establish behavioral correlates of identified circuit features (circuit function), attaching relevance to connectomics data in a way that is achievable only by a wide, comparative approach - raising our understanding of structure-function relations in animal nervous systems to a new level.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2021-COG

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Host institution

LUNDS UNIVERSITET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 999 119,00
Address
Paradisgatan 5c
22100 Lund
Sweden

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 999 119,00

Beneficiaries (1)

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