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Understanding the host-environmental interactions across the lifespan determining lung function trajectories and COPD

Objective

Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have proposed that the pathogenesis of COPD goes beyond smoking, and that there is a range of lung function trajectories through life (trajectome); some of them have roots in early life and can lead to COPD, cardiovascular and metabolic morbidity as well as premature death, while others are associated with healthy ageing. Here I propose that, detrimental gene (G) and environment (E) interactions occurring early in life (T) constitute a ‘first injury hit’ that alters the normal lung developmental program and modify the pace of normal lung aging by reducing the resilience of the lungs to future GxExT interactions. Accordingly, lifelong GxExT interactions determine the individual trajectome and, eventually, the occurrence of COPD and associated multimorbidity. PredictCOPD aims to identify the interactions and mechanisms that determine which individuals will develop COPD and multimorbidty at some point of their life.
The specific aims are: 1) to identify the lifelong environmental and host risk factors associated with the trajectome, COPD and multimorbidity, 2) to use a novel liquid biopsy method to identify biological factors driving the trajectome, COPD and multimorbidity; 3) to identify clinically relevant preventive and/or early therapeutic targets integrating the results from aims 1 and 2 with novel analytical approaches and 4) to validate findings both in vitro and in other available cohorts.
The project will leverage from several available population and COPD patient studies with available clinical data and biological samples. The results of PredictCOPD have the potential to: 1) promote healthy ageing by preventing and eventually eradicate COPD and associated multimorbidity; and, 2) change COPD treatment from palliative to causal.

Coordinator

UNIVERSITAT DE BARCELONA
Net EU contribution
€ 839 123,75
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Other funding
€ 839 123,75

Participants (3)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
Net EU contribution
€ 30 001,50
Address
Calle Monforte De Lemos 5
28029 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 30 001,50
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 253 750,00
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 253 750,00
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
Net EU contribution
€ 875 443,75
Address
Carrer Rossello 149
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 875 443,75