CenTral and PeRipheral NervoUs SyStem acTion of GIPR in ObEsity and Diabetes

Project Information

TRUSTED

Grant agreement ID: 101044445

DOI

10.3030/101044445

EC signature date 28 April 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 928,75

EU contribution

€ 1 999 928,75

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (24)

Peptides

Author(s): Novikoff A, Müller TD
Published in: Peptides, 2023, ISSN 0196-9781
Publisher: Elsevier
DOI: 10.1016/j.peptides.2023.171003

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

Author(s): Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
Published in: Cell Reports, Issue 42, 2023, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/j.celrep.2023.113305

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Author(s): Arkadiusz Liskiewicz, Ahmed Khalil, Daniela Liskiewicz, Aaron Novikoff, Gerald Grandl, Gandhari Maity-Kumar, Robert M. Gutgesell, Mostafa Bakhti, Aimée Bastidas-Ponce, Oliver Czarnecki, Konstantinos Makris, Heiko Lickert, Annette Feuchtinger, Monica Tost, Callum Coupland, Lisa Ständer, Seun Akindehin, Sneha Prakash, Faiyaz Abrar, Russell L. Castelino, Yantao He, Patrick J. Knerr, Bin Yang, Wouter F. J. Hogendorf, Shiqi Zhang, Susanna M. Hofmann, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Jonathan D. Douros, Timo D. Müller
Published in: Nature Metabolism, Issue 5, 2023, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00931-7

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Author(s): Kimberley El; Jonathan D. Douros; Francis S. Willard; Aaron Novikoff; Ashot Sargsyan; Diego Perez-Tilve; David B. Wainscott; Bin Yang; Alex Chen; Donald Wothe; Callum Coupland; Mattias H. Tschöp; Brian Finan; David A. D’Alessio; Kyle W. Sloop; Timo D. Müller; Jonathan E. Campbell
Published in: Nature Metabolism, 2023, ISSN 2522-5812
Publisher: Springer Nature
DOI: 10.1038/s42255-023-00811-0

Transforming obesity: The advancement of multi-receptor drugs

Author(s): Christine M. Kusminski, Diego Perez-Tilve, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Philipp E. Scherer
Published in: Cell, Issue 187, 2024, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/j.cell.2024.06.003

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Author(s): Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, null Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
Published in: Nature Metabolism, 2024, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-00991-3

A spatiotemporal proteomic map of human adipogenesis

Author(s): Felix Klingelhuber, Scott Frendo-Cumbo, Muhmmad Omar-Hmeadi, Lucas Massier, Pamela Kakimoto, Austin J. Taylor, Morgane Couchet, Sara Ribicic, Martin Wabitsch, Ana C. Messias, Arcangela Iuso, Timo D. Müller, Mikael Rydén, Niklas Mejhert, Natalie Krahmer
Published in: Nature Metabolism, Issue 6, 2024, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01025-8

Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don’t

Author(s): Aaron Novikoff, Timo D. Müller
Published in: Physiology, Issue 39, 2024, ISSN 1548-9213
Publisher: American Physiological Society
DOI: 10.1152/physiol.00032.2023

Cardiovascular Diabetology

Author(s): Stephan Sachs; Anna Götz; Brian Finan; Annette Feuchtinger; Richard D. DiMarchi; Yvonne Döring; Christian Weber; Matthias H. Tschöp; Timo D. Müller; Susanna M. Hofmann
Published in: Cardiovascular Diabetology, 2023, ISSN 1475-2840
Publisher: Springer Nature
DOI: 10.1186/s12933-023-01940-2

Incretin hormones and type 2 diabetes

Author(s): Michael A, Nauck; Timo D, Müller
Published in: Diabetologia, 2023, ISSN 1432-0428
Publisher: Springer Nature
DOI: 10.1007/s00125-023-05956-x

Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain

Author(s): De Angelis, M, Maity-Kumar, G., Schriever, S.C., Kozlova, E.V., Müller, T.D., Pfluger, P.T., Curras-Collazo, M.C., Schramm, K.W.
Published in: Journal of Pharmaceutical and Biomedical Analysis, 2022, ISSN 0731-7085
Publisher: Elsevier BV
DOI: 10.1016/j.jpba.2022.115038

100 years of glucagon and 100 more

Author(s): Nicolai J. Wewer Albrechtsen, Jens J. Holst, Alan D. Cherrington, Brian Finan, Lise Lotte Gluud, E. Danielle Dean, Jonathan E. Campbell, Stephen R. Bloom, Tricia M.-M. Tan, Filip K. Knop, Timo D. Müller
Published in: Diabetologia, Issue 66, 2024, ISSN 0012-186X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00125-023-05947-y

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins II: Intercellular Transfer of Matter (Inheritance?) That Matters

Author(s): Günter A. Müller, Timo D. Müller
Published in: Biomolecules, Issue 13, 2023, ISSN 2218-273X
Publisher: MDPI AG
DOI: 10.3390/biom13060994

Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes

Author(s): Robert M. Gutgesell, Rubén Nogueiras, Matthias H. Tschöp, Timo D. Müller
Published in: Diabetes Therapy, Issue 15, 2024, ISSN 1869-6953
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s13300-024-01566-x

Cell Metabolism

Author(s): Sekar, Revathi; Motzler, Karsten; Kwon, Yun; Novikoff, Aaron; Jülg, Julia; Najafi, Bahar; Wang, Surui; Warnke, Anna-Luisa; Seitz, Susanne; Hass, Daniela; Gancheva, Sofiya; Kahl, Sabine; Yang, Bin; Finan, Brian; Schwarz, Kathrin; Okun, Juergen G.; Roden, Michael; Blüher, Matthias; Müller, Timo D.; Krahmer, Natalie; Behrends, Christian; Plettenburg, Oliver; Miaczynska, Marta; Herzig, Stephan; Zeigerer, Anja
Published in: Cell metabolism, 2022, ISSN 1932-7420
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.10.013

Cell Metabolism

Author(s): González-García, Ismael; García-Clavé, Elena; Cebrian-Serrano, Alberto; Le Thuc, Ophélia; Contreras, Raian E.; Xu, Yanjun; Gruber, Tim; Schriever, Sonja C.; Legutko, Beata; Lintelmann, Jutta; Adamski, Jerzy; Wurst, Wolfgang; Müller, Timo D.; Woods, Stephen C.; Pfluger, Paul T.; Tschöp, Matthias H.; Fisette, Alexandre; García-Cáceres, Cristina
Published in: Cell metabolism, 2023, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2023.02.004

Regulation of energy metabolism through central GIPR signaling

Author(s): Arkadiusz Liskiewicz, Timo D. Müller
Published in: Peptides, Issue 176, 2024, ISSN 0196-9781
Publisher: Elsevier BV
DOI: 10.1016/j.peptides.2024.171198

Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs

Author(s): Günter A. Müller, Timo D. Müller
Published in: International Journal of Molecular Sciences, Issue 24, 2023, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms24054825

SURMOUNTing body weight barriers in type 2 diabetes

Author(s): Aaron Novikoff, Timo D. Müller
Published in: Med, Issue 4, 2023, ISSN 2666-6340
Publisher: Elsevier BV
DOI: 10.1016/j.medj.2023.11.007

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Author(s): Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Published in: Molecular Metabolism, Issue 83, 2024, ISSN 2212-8778
Publisher: Elsevier BV
DOI: 10.1016/j.molmet.2024.101915

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

Author(s): Jonathan E. Campbell, Timo D. Müller, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, David A. D’Alessio
Published in: Cell Metabolism, Issue 35, 2023, ISSN 1550-4131
Publisher: Elsevier BV
DOI: 10.1016/j.cmet.2023.07.010

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments

Author(s): Günter A. Müller, Timo D. Müller
Published in: Biomolecules, Issue 13, 2023, ISSN 2218-273X
Publisher: MDPI AG
DOI: 10.3390/biom13050855

Nature Communications

Author(s): Konxhe Kulaj; Alexandra Harger; Michaela Bauer; Özüm S. Caliskan; Tilak Kumar Gupta; Dapi Menglin Chiang; Edward Milbank; Josefine Reber; Angelos Karlas; Petra Kotzbeck; David N. Sailer; Francesco Volta; Dominik Lutter; Sneha Prakash; Juliane Merl-Pham; Vasilis Ntziachristos; Hans Hauner; Michael W. Pfaffl; Matthias H. Tschöp; Timo D. Müller; Stefanie M. Hauck; Benjamin D. Engel; Jantje M. Gerdes; Paul T. Pfluger; Natalie Krahmer; Kerstin Stemmer
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.5451/unibas-ep95532

Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice

Author(s): Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut, Hannah Marchi, Monir Majzoub-Altweck, Patrick J. Knerr, Jonathan D. Douros, Timo D. Müller, Markus Brielmeier
Published in: Molecular Metabolism, Issue 87, 2024, ISSN 2212-8778
Publisher: Elsevier BV
DOI: 10.1016/j.molmet.2024.101992