CenTral and PeRipheral NervoUs SyStem acTion of GIPR in ObEsity and Diabetes

Información del proyecto

TRUSTED

Identificador del acuerdo de subvención: 101044445

DOI

10.3030/101044445

Fecha de la firma de la CE 28 Abril 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 1 999 928,75

Aportación de la UE

€ 1 999 928,75

Coordinado por

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (24)

Peptides

Autores: Novikoff A, Müller TD
Publicado en: Peptides, 2023, ISSN 0196-9781
Editor: Elsevier
DOI: 10.1016/j.peptides.2023.171003

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

Autores: Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
Publicado en: Cell Reports, Edición 42, 2023, ISSN 2211-1247
Editor: Elsevier BV
DOI: 10.1016/j.celrep.2023.113305

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Autores: Arkadiusz Liskiewicz, Ahmed Khalil, Daniela Liskiewicz, Aaron Novikoff, Gerald Grandl, Gandhari Maity-Kumar, Robert M. Gutgesell, Mostafa Bakhti, Aimée Bastidas-Ponce, Oliver Czarnecki, Konstantinos Makris, Heiko Lickert, Annette Feuchtinger, Monica Tost, Callum Coupland, Lisa Ständer, Seun Akindehin, Sneha Prakash, Faiyaz Abrar, Russell L. Castelino, Yantao He, Patrick J. Knerr, Bin Yang, Wouter F. J. Hogendorf, Shiqi Zhang, Susanna M. Hofmann, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, Jonathan D. Douros, Timo D. Müller
Publicado en: Nature Metabolism, Edición 5, 2023, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00931-7

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Autores: Kimberley El; Jonathan D. Douros; Francis S. Willard; Aaron Novikoff; Ashot Sargsyan; Diego Perez-Tilve; David B. Wainscott; Bin Yang; Alex Chen; Donald Wothe; Callum Coupland; Mattias H. Tschöp; Brian Finan; David A. D’Alessio; Kyle W. Sloop; Timo D. Müller; Jonathan E. Campbell
Publicado en: Nature Metabolism, 2023, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-023-00811-0

Transforming obesity: The advancement of multi-receptor drugs

Autores: Christine M. Kusminski, Diego Perez-Tilve, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Philipp E. Scherer
Publicado en: Cell, Edición 187, 2024, ISSN 0092-8674
Editor: Elsevier BV
DOI: 10.1016/j.cell.2024.06.003

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Autores: Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, null Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
Publicado en: Nature Metabolism, 2024, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-00991-3

A spatiotemporal proteomic map of human adipogenesis

Autores: Felix Klingelhuber, Scott Frendo-Cumbo, Muhmmad Omar-Hmeadi, Lucas Massier, Pamela Kakimoto, Austin J. Taylor, Morgane Couchet, Sara Ribicic, Martin Wabitsch, Ana C. Messias, Arcangela Iuso, Timo D. Müller, Mikael Rydén, Niklas Mejhert, Natalie Krahmer
Publicado en: Nature Metabolism, Edición 6, 2024, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01025-8

Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don’t

Autores: Aaron Novikoff, Timo D. Müller
Publicado en: Physiology, Edición 39, 2024, ISSN 1548-9213
Editor: American Physiological Society
DOI: 10.1152/physiol.00032.2023

Cardiovascular Diabetology

Autores: Stephan Sachs; Anna Götz; Brian Finan; Annette Feuchtinger; Richard D. DiMarchi; Yvonne Döring; Christian Weber; Matthias H. Tschöp; Timo D. Müller; Susanna M. Hofmann
Publicado en: Cardiovascular Diabetology, 2023, ISSN 1475-2840
Editor: Springer Nature
DOI: 10.1186/s12933-023-01940-2

Incretin hormones and type 2 diabetes

Autores: Michael A, Nauck; Timo D, Müller
Publicado en: Diabetologia, 2023, ISSN 1432-0428
Editor: Springer Nature
DOI: 10.1007/s00125-023-05956-x

Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain

Autores: De Angelis, M, Maity-Kumar, G., Schriever, S.C., Kozlova, E.V., Müller, T.D., Pfluger, P.T., Curras-Collazo, M.C., Schramm, K.W.
Publicado en: Journal of Pharmaceutical and Biomedical Analysis, 2022, ISSN 0731-7085
Editor: Elsevier BV
DOI: 10.1016/j.jpba.2022.115038

100 years of glucagon and 100 more

Autores: Nicolai J. Wewer Albrechtsen, Jens J. Holst, Alan D. Cherrington, Brian Finan, Lise Lotte Gluud, E. Danielle Dean, Jonathan E. Campbell, Stephen R. Bloom, Tricia M.-M. Tan, Filip K. Knop, Timo D. Müller
Publicado en: Diabetologia, Edición 66, 2024, ISSN 0012-186X
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00125-023-05947-y

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins II: Intercellular Transfer of Matter (Inheritance?) That Matters

Autores: Günter A. Müller, Timo D. Müller
Publicado en: Biomolecules, Edición 13, 2023, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom13060994

Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes

Autores: Robert M. Gutgesell, Rubén Nogueiras, Matthias H. Tschöp, Timo D. Müller
Publicado en: Diabetes Therapy, Edición 15, 2024, ISSN 1869-6953
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s13300-024-01566-x

Cell Metabolism

Autores: Sekar, Revathi; Motzler, Karsten; Kwon, Yun; Novikoff, Aaron; Jülg, Julia; Najafi, Bahar; Wang, Surui; Warnke, Anna-Luisa; Seitz, Susanne; Hass, Daniela; Gancheva, Sofiya; Kahl, Sabine; Yang, Bin; Finan, Brian; Schwarz, Kathrin; Okun, Juergen G.; Roden, Michael; Blüher, Matthias; Müller, Timo D.; Krahmer, Natalie; Behrends, Christian; Plettenburg, Oliver; Miaczynska, Marta; Herzig, Stephan; Zeigerer, Anja
Publicado en: Cell metabolism, 2022, ISSN 1932-7420
Editor: Cell Press
DOI: 10.1016/j.cmet.2022.10.013

Cell Metabolism

Autores: González-García, Ismael; García-Clavé, Elena; Cebrian-Serrano, Alberto; Le Thuc, Ophélia; Contreras, Raian E.; Xu, Yanjun; Gruber, Tim; Schriever, Sonja C.; Legutko, Beata; Lintelmann, Jutta; Adamski, Jerzy; Wurst, Wolfgang; Müller, Timo D.; Woods, Stephen C.; Pfluger, Paul T.; Tschöp, Matthias H.; Fisette, Alexandre; García-Cáceres, Cristina
Publicado en: Cell metabolism, 2023, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2023.02.004

Regulation of energy metabolism through central GIPR signaling

Autores: Arkadiusz Liskiewicz, Timo D. Müller
Publicado en: Peptides, Edición 176, 2024, ISSN 0196-9781
Editor: Elsevier BV
DOI: 10.1016/j.peptides.2024.171198

Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs

Autores: Günter A. Müller, Timo D. Müller
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/ijms24054825

SURMOUNTing body weight barriers in type 2 diabetes

Autores: Aaron Novikoff, Timo D. Müller
Publicado en: Med, Edición 4, 2023, ISSN 2666-6340
Editor: Elsevier BV
DOI: 10.1016/j.medj.2023.11.007

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

Autores: Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Publicado en: Molecular Metabolism, Edición 83, 2024, ISSN 2212-8778
Editor: Elsevier BV
DOI: 10.1016/j.molmet.2024.101915

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

Autores: Jonathan E. Campbell, Timo D. Müller, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, David A. D’Alessio
Publicado en: Cell Metabolism, Edición 35, 2023, ISSN 1550-4131
Editor: Elsevier BV
DOI: 10.1016/j.cmet.2023.07.010

(Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins I: Localization at Plasma Membranes and Extracellular Compartments

Autores: Günter A. Müller, Timo D. Müller
Publicado en: Biomolecules, Edición 13, 2023, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom13050855

Nature Communications

Autores: Konxhe Kulaj; Alexandra Harger; Michaela Bauer; Özüm S. Caliskan; Tilak Kumar Gupta; Dapi Menglin Chiang; Edward Milbank; Josefine Reber; Angelos Karlas; Petra Kotzbeck; David N. Sailer; Francesco Volta; Dominik Lutter; Sneha Prakash; Juliane Merl-Pham; Vasilis Ntziachristos; Hans Hauner; Michael W. Pfaffl; Matthias H. Tschöp; Timo D. Müller; Stefanie M. Hauck; Benjamin D. Engel; Jantje M. Gerdes; Paul T. Pfluger; Natalie Krahmer; Kerstin Stemmer
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.5451/unibas-ep95532

Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice

Autores: Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut, Hannah Marchi, Monir Majzoub-Altweck, Patrick J. Knerr, Jonathan D. Douros, Timo D. Müller, Markus Brielmeier
Publicado en: Molecular Metabolism, Edición 87, 2024, ISSN 2212-8778
Editor: Elsevier BV
DOI: 10.1016/j.molmet.2024.101992