Project description
Understanding leukaemia’s interaction with its micro-environment
Acute myeloid leukaemia (AML), a cancer of the blood and bone marrow, is the most common type of acute leukaemia in adults. Failure to eradicate leukaemia stem cells (LSCs), with their limitless self-renewal, results in relapse. Recent studies suggest bone marrow stromal and immune cells play a significant role in AML. Building on data suggesting that AML’s remodelling of its microenvironment (niche) favours its survival and represses healthy blood cell formation, the EU funded epiNicheAML project will take a new approach. Investigating the interplay among LSC intrinsic, stromal niche and immune-mediated mechanisms rather than studying each individually could point to new therapies focused on restoring a healthy niche for healthy immunity rather than eradicating all LSCs.
Fields of science
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencescomputer and information sciencescomputational science
- medical and health sciencesbasic medicinepathology
- medical and health sciencesclinical medicineoncologyleukemia
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Funding Scheme
HORIZON-AG - HORIZON Action Grant Budget-BasedCoordinator
69117 Heidelberg
Germany
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