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Mechanistic models of leukemia-niche interaction using multimodal single cell profiling

Project description

Understanding leukaemia’s interaction with its micro-environment

Acute myeloid leukaemia (AML), a cancer of the blood and bone marrow, is the most common type of acute leukaemia in adults. Failure to eradicate leukaemia stem cells (LSCs), with their limitless self-renewal, results in relapse. Recent studies suggest bone marrow stromal and immune cells play a significant role in AML. Building on data suggesting that AML’s remodelling of its microenvironment (niche) favours its survival and represses healthy blood cell formation, the EU funded epiNicheAML project will take a new approach. Investigating the interplay among LSC intrinsic, stromal niche and immune-mediated mechanisms rather than studying each individually could point to new therapies focused on restoring a healthy niche for healthy immunity rather than eradicating all LSCs.

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Net EU contribution
€ 2 000 000,00
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Other funding
€ 0,00