Project description
New management of unruptured brain aneurysms
Unruptured brain aneurysms can be challenging to treat. Sometimes it is best to monitor the patient (watchful waiting), while other times doctors will decide to treat the aneurysm. Treating blood pressure is one approach; another is to surgically place a clip across the aneurysm or insert a coil into it. The ERC-funded CURE project plans to reshape the future of intracranial aneurysm risk management. It will develop a novel capability to predict the risk of rupture and to improve treatment outcomes in the follow-up of endovascular repair. Specifically, it will identify and characterise novel flow-deviator stent devices through a high-fidelity computational framework combined with machine learning. If successful, CURE's technique will improve patient outcomes, saving millions of lives worldwide.
Objective
Developing new capabilities to predict the risk of intracranial aneurysm rupture and to improve treatment outcomes in the follow-up of endovascular repair is of tremendous medical and societal interest, both to support decision-making and assessment of treatment options by medical doctors, and to improve the life quality and expectancy of patients.
The proposal aims at identifying and characterizing novel flow-deviator stent devices through a high-fidelity computational framework that combines state-of-the-art numerical methods for fluid-structure interaction modeling (to accurately describe the mechanical exchanges between the blood flow, the surrounding vessel tissue, and the flow-deviator) and deep reinforcement learning algorithms (to identify and to invent a new stent concepts enabling patient-specific treatment via accurate adjustment of the functional parameters in the implanted state). This has never been done before in this context and should thus open both new theoretical and numerical opportunities.
CURE takes the vital steps of bringing novel computational and optimization frameworks to the next level capable of studying the selected flow diverter treatment in order to reduce the risk of hemorrhage in cerebral aneurysms, of supporting the decisions of treatment options by medical doctors and finally of providing guidance in the development of new implant design. Such unique capabilities can save millions of lives worldwide, improve the life quality of patients, eliminate lifelong side-effects due to sub-optimal treatment planning and delivery; and reduce the tremendous societal and economic burden linked to poor patient outcome.
The proposed work has potential to reshape the future of intracranial aneurysm risk management. It is highly multidisciplinary, and the methods proposed and developed as a part of this research can be quickly adapted to a wide range of engineering and bio-medical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences medical biotechnology implants
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75272 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.