EARLY DETECTION AND INTERVENTION IN SMOLDERING MULTIPLE MYELOMA: POPULATION-BASED SCREENING AND TREATMENT

Project Information

Edit-SMM

Grant agreement ID: 101045549

DOI

10.3030/101045549

EC signature date 23 May 2022

Start date 1 June 2022

End date 31 May 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 998 145,00

EU contribution

€ 1 998 145,00

Coordinated by

HASKOLI ISLANDS
Iceland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies: an iSTOPMM study

Author(s): Oihane Pérez-Escurza,1,2,3 Juan Flores-Montero,1,2,3,4,5 Jón Þórir Óskarsson,6 Luzalba Sanoja-Flores,4,7 Julio del Pozo,1 Quentin Lecrevisse,1,2,3,4 Silvia Martín,1 Elín Ruth Reed,6 Guðlaug Katrín Hákonardóttir,6 Stephen Harding,8 Sigrún Þorsteinsdóttir,6
Published in: Blood Cancer Journal, Issue 2023 Dec; 12(1): 182, 2023, ISSN 2044-5385
Publisher: Springer Nature
DOI: 10.1038/s41408-023-00944-1

Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance: An Analysis From a Population-Based Screening Study

Author(s): Ingigerdur Sverrisdottir, MD https://orcid.org/0000-0003-2353-573X, Sigrun Thorsteinsdottir, MD, PhD https://orcid.org/0000-0001-5017-3530, Sæmundur Rognvaldsson, MD, PhD https://orcid.org/0000-0003-2162-8414, Thor Aspelund, PhD https://orcid.org/0000-00
Published in: Annals of Internal Medicine, Issue Volume 177, number 6, 2024, ISSN 0003-4819
Publisher: American College of Physicians (ACP)
DOI: 10.7326/M23-2867

Development of a Multivariable Model to Predict the Need for Bone Marrow Sampling in Persons With Monoclonal Gammopathy of Undetermined Significance : A Cohort Study Nested in a Clinical Trial

Author(s): Elias Eythorsson; Saemundur Rognvaldsson; Sigrun Thorsteinsdottir; Thorir Einarsson Long; Elin Ruth Reed; Gudrun Asta Sigurdardottir; Brynjar Vidarsson; Pall Torfi Onundarson; Bjarni A. Agnarsson; Margret Sigurdardottir; Isleifur Olafsson; Ingunn Thorsteinsdottir; Signy Vala Sveinsdottir; Fridbjorn Sigurdsson; Asdis Rosa Thordardottir; Runolfur Palsson; Olafur Skuli Indridason; Asbjorn Jonsson; Gauti Kjartan Gislason; Andri Olafsson; Jon Sigurdsson; Hlif Steingrimsdottir; Malin Hultcrantz; Brian G.M. Durie; Stephen Harding; Ola Landgren; Thor Aspelund; Thorvardur Jon Love; Sigurdur Yngvi Kristinsson
Published in: Annals of Internal Medicine, Issue Volume 177, Number 4, 2024, ISSN 0003-4819
Publisher: American College of Physicians (ACP)
DOI: 10.7326/m23-2540

Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry: Proposal for a bone marrow quality index

Author(s): Jón Þórir Óskarsson,corresponding author1 Sæmundur Rögnvaldsson,1,2 Sigrun Thorsteinsdottir,1,3 Thor Aspelund,4 Steinar Bragi Gunnarsson,1 Guðlaug Katrín Hákonardóttir,1 Guðrún Ásta Sigurðardóttir,1 Ásdís Rósa Þórðardóttir,1 Gauti Kjartan Gíslason,1 Andri
Published in: Blood Cancer Journal, Issue 2023 Dec; 13(1): 177, 2023, ISSN 2044-5385
Publisher: Springer Nature
DOI: 10.1038/s41408-023-00951-2

The consultant's guide to smoldering multiple myeloma

Author(s): Sigrun Thorsteinsdottir, Sigurdur Yngvi Kristinsson
Published in: Hematology, ASH Education Program, Issue 2022 Dec 9; 2022 (1):551-559, 2022, ISSN 1520-4391
Publisher: American Society of Hematology (ASH)
DOI: 10.1182/hematology.2022000355

Screening in Multiple Myeloma and Its Precursors: Are We There Yet?

Author(s): Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Sigurður Yngvi Kristinsson
Published in: Clinical Chemistry, Issue Volume 70, Issue 1, 2024, ISSN 0009-9147
Publisher: Oxford Academic
DOI: 10.1093/clinchem/hvad148

Prevalence of smoldering multiple myeloma based on nationwide screening

Author(s): Sigrun Thorsteinsdottir, Gauti K Gislason, Thor Aspelun, Saemundur Rognvaldsson, Jon Thorir Oskarsson, Sigurdur Yngvi Kristinsson
Published in: Nature Medicine, Issue 2023 Feb; 29(2): 467-472, 2023, ISSN 1078-8956
Publisher: Springer Nature
DOI: 10.1038/s41591-022-02183-6

Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study

Author(s): Aðalbjörg Ýr Sigurbergsdóttir, 1 Sæmundur Rögnvaldsson, 1 , 2 Sigrún Thorsteinsdóttir, 1 , 3 Ingigerður Sverrisdóttir, 1 , 4 Guðrún Ásta Sigurðardóttir, 1 Brynjar Viðarsson, 2 Páll Torfi Önundarson, 1 , 2 Bjarni A. Agnarsson, 2 Margrét Sigurðardóttir, 2 I
Published in: Haematologica, Issue 2023 Dec 1; 108 (12): 3392-3398, 2023, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.283191

Conference proceedings (16)

Prevalence of MGUS Is High in the Istopmm Study but the Prevalence of IgA MGUS Does Not Increase with Age in the Way Other Immunoglobulin Subtypes Do

Author(s): Thorvardur Jon Love, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Thor Aspelund, Elin Ruth Reed, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Isleifur Olafss
Published in: Blood, Issue Volum 140, Issue Supplement 1: 256-258, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-163169

P900: INVOLVED/UNINVOLVED SERUM FREE LIGHT CHAIN RATIO IS A STRONGER PREDICTOR OF DIAGNOSTIC/RISK FACTORS IN LIGHT CHAIN COMPARED TO HEAVY CHAIN MONOCLONAL GAMMOPATHIES

Author(s): Jon Thorir Oskarsson,1 Sigrún Þorsteinsdóttir,1 Sæmundur Rögnvaldsson,1 Guðrún Ásta Sigurðardóttir,1 Ásdís Rósa Þórðardóttir,1 Gauti Kjartan Gíslason,1 Andri Ólafsson,1 Jón Kristinn Sigurðsson,1 Elías Eyþórsson,3 Ásbjörn Jónsson,4 Brynjar Viðarsson,3 Páll
Published in: HemaSphere, Issue 7 (supple): e15034c8, 2023, ISSN 2572-9241
Publisher: The European Hematology Association
DOI: 10.1097/01.HS9.0000970504.15034.c8

Autoimmune Diseases Are Not Associated with Monoclonal Gammopathy of Undetermined Significance: Results of the Prospective Population-Based Istopmm Study

Author(s): Ingigerdur S Sverrisdottir, Sigrún Thorsteinsdóttir, Sæmundur Rögnvaldsson, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Önundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Robert Palmason, Ísleifur Ólaf
Published in: Blood, Issue Vol 140, Supplement 1: 10031-10032, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-169393

Predicting an Underlying Clonal Plasma Cell Population in Light-Chain Monoclonal Gammopathy of Undetermined Significance Using Free Light-Chain Ratio

Author(s): Jon Thorir Oskarsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Thorir E. Long, Gudrun Asta Sigurdardottir, Asdis Rosa Thordardottir, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Elias Eythorsson, Asbjorn Jonsson, Brynjar Vidarsson, Pall
Published in: Blood, Issue Vol 142 Supplement 1: 530, 2023, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2023-182661

Monoclonal Gammopathy of Undetermined Significance (MGUS) with Multiple Paraproteins: Results from the Population-Based Istopmm Screening Study

Author(s): Sæmundur Rögnvaldsson, Jon Þórir Oskarsson, Sigrun Thorsteinsdottir, Elin Ruth Reed, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Margret Sigurdardottir, Bjarni Agnar Agnarsson, Isleifur Olafsson, Ingunn Thorsteinsdottir, Signy Va
Published in: Blood, Issue Vol 140, Supplement 1: 10024-10026, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-168070

Revised Definition of Free Light Chains in Serum and Light Chain Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Author(s): Thorir Einarsson Long, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Olafur Indridason, Runolfur Palsson, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Ingunn
Published in: Blood, Issue Vol 142 Supplement 1: 535, 2023, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2023-188547

Transient M-Proteins: Epidemiology, Causes, and the Impact of Mass Spectrometry: The Istopmm Study

Author(s): Robert Palmason, Oscar Berlanga, Jon Kristinn Sigurdsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Sara Ekberg, Michael Crowther, Marina Levy, Elin Ruth Reed, Jon Þórir Oskarsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson
Published in: Blood, Issue Blood(2022) 140(Supplement 1):2338-2340, 2022, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2022-164758

Monoclonal Gammopathy of Undetermined Significance and the Risk of Thrombotic Events: Results from Istopmm, a Population-Based Screening Study in Iceland

Author(s): Sæmundur Rögnvaldsson, Alessandro Gasparini, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Thorir E. Long, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir,
Published in: Blood, Issue Vol 142, Supplement 1: 216, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2023-186098

Predicting the Need for Upfront Bone Marrow Sampling in Individuals with MGUS: Derivation of a Multivariable Prediction Model Using the Prospective Population-Based Istopmm Cohort

Author(s): Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Elin Ruth Reed, Gudrún Ásta Sigurdardóttir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ísleifur Ólafsson, Ingunn Þorsteinsdóttir, Signy Vala Sveinsd
Published in: Blood, Issue Volume 140, Supplement 1: 266-267, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-170166

Detection of abnormal plasma cells by multiparameter flow cytometry in a screened cohort of patients with monoclonal gammopathy of undetermined significance

Author(s): Jón Þórir Óskarsson , Sæmundur Rögnvaldsson , Sigrún Þorsteinsdóttir , Íris Pétursdóttir , Hrafnhildur Una Þórðardóttir , Steinar Bragi Gunnarsson , Guðlaug Katrín Hákonardóttir , Guðrún Ásta Sigurðardóttir , Ásdís Rósa Þórðardóttir , Gauti Kjart
Published in: Clinical Lymphoma Myeloma and Leukemia, Issue Volume 22, Supplement, August 2022, page S22, 2022, ISSN 2152-2650
Publisher: Elsevier
DOI: 10.1016/S2152-2650(22)00310-X

Monoclonal Gammopathy of Undetermined Significance and Risk of Chronic Kidney Disease: Results of the Population-Based Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Author(s): Thorir Einarsson Long, Elias Eythorsson, Sæmundur Rögnvaldsson, Olafur Indridason, Runolfur Palsson, Sigrún Thorsteinsdóttir, Ingigerdur S Sverrisdottir, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, In
Published in: Blood, Issue Volume 140, supplement 1: 10108-10109, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-170623

Risk factors of smoldering multiple myeloma: Results from the screened iStopMM study

Author(s): Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Saemundur Rognvaldsson, Sigurdur Yngvi Kristinsson
Published in: Blood, 2023, ISSN 1528-0020
Publisher: The American Society of Hematology
DOI: 10.1182/blood-2023-188469

The Early Benefits and Psychological Effects of Screening for Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Author(s): Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Jon Oskarsson, Elias Eythorsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Andri Steinthor Bjorn
Published in: Blood, Issue Vol 142 Supplement 1: 214, 2023, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2023-186397

Sars-Cov-2 Infection Does Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study

Author(s): Robert Palmason, Sara Ekberg, Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Michael Crowther, Elin Ruth Reed, Jon Oskarsson, Gudrun Asta Sigurdardottir, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Si
Published in: Blood, Issue Vol 142 Supplement 1: 4766, 2023, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2023-173078

Circulating Tumor Plasma Cells in the Screened Istopmm Smoldering Multiple Myeloma Cohort

Author(s): Sigrún Thorsteinsdóttir, Jon Þórir Oskarsson, Sæmundur Rögnvaldsson, Gauti Gíslason, Thor Aspelund, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnar Agnarsson, Margrét Sigurdardóttir, Ingunn Thor
Published in: Blood, Issue Vol 140, Supplement 1: 9923-9924, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-168690

Determining Hemodilution in Diagnostic Bone Marrow Samples in Multiple Myeloma and Its Precursors By Next-Generation Flow Cytometry: Data from the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Author(s): Jón Þórir Óskarsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Hrafnhildur Una þórðardóttir, Gudlaug Katrin Hakonardottir, Steinar Bragi Gunnarsson, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Gauti Gíslason, Andri Olafsson, Jon Kristinn S
Published in: Blood, Issue Vol 140 Supplement 1: 7166-7167, 2022, ISSN 0006-4971
Publisher: ASH Publications
DOI: 10.1182/blood-2022-168741