EARLY DETECTION AND INTERVENTION IN SMOLDERING MULTIPLE MYELOMA: POPULATION-BASED SCREENING AND TREATMENT

Projektinformationen

Edit-SMM

ID Finanzhilfevereinbarung: 101045549

DOI

10.3030/101045549

EK-Unterschriftsdatum 23 Mai 2022

Startdatum 1 Juni 2022

Enddatum 31 Mai 2027

Finanziert unter

• European Research Council (ERC)

Gesamtkosten

€ 1 998 145,00

EU-Beitrag

€ 1 998 145,00

Koordiniert durch

HASKOLI ISLANDS
Iceland

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Veröffentlichungen

Peer reviewed articles (8)

Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies: an iSTOPMM study

Autoren: Oihane Pérez-Escurza,1,2,3 Juan Flores-Montero,1,2,3,4,5 Jón Þórir Óskarsson,6 Luzalba Sanoja-Flores,4,7 Julio del Pozo,1 Quentin Lecrevisse,1,2,3,4 Silvia Martín,1 Elín Ruth Reed,6 Guðlaug Katrín Hákonardóttir,6 Stephen Harding,8 Sigrún Þorsteinsdóttir,6
Veröffentlicht in: Blood Cancer Journal, Ausgabe 2023 Dec; 12(1): 182, 2023, ISSN 2044-5385
Herausgeber: Springer Nature
DOI: 10.1038/s41408-023-00944-1

Association Between Autoimmune Diseases and Monoclonal Gammopathy of Undetermined Significance: An Analysis From a Population-Based Screening Study

Autoren: Ingigerdur Sverrisdottir, MD https://orcid.org/0000-0003-2353-573X, Sigrun Thorsteinsdottir, MD, PhD https://orcid.org/0000-0001-5017-3530, Sæmundur Rognvaldsson, MD, PhD https://orcid.org/0000-0003-2162-8414, Thor Aspelund, PhD https://orcid.org/0000-00
Veröffentlicht in: Annals of Internal Medicine, Ausgabe Volume 177, number 6, 2024, ISSN 0003-4819
Herausgeber: American College of Physicians (ACP)
DOI: 10.7326/M23-2867

Development of a Multivariable Model to Predict the Need for Bone Marrow Sampling in Persons With Monoclonal Gammopathy of Undetermined Significance : A Cohort Study Nested in a Clinical Trial

Autoren: Elias Eythorsson; Saemundur Rognvaldsson; Sigrun Thorsteinsdottir; Thorir Einarsson Long; Elin Ruth Reed; Gudrun Asta Sigurdardottir; Brynjar Vidarsson; Pall Torfi Onundarson; Bjarni A. Agnarsson; Margret Sigurdardottir; Isleifur Olafsson; Ingunn Thorsteinsdottir; Signy Vala Sveinsdottir; Fridbjorn Sigurdsson; Asdis Rosa Thordardottir; Runolfur Palsson; Olafur Skuli Indridason; Asbjorn Jonsson; Gauti Kjartan Gislason; Andri Olafsson; Jon Sigurdsson; Hlif Steingrimsdottir; Malin Hultcrantz; Brian G.M. Durie; Stephen Harding; Ola Landgren; Thor Aspelund; Thorvardur Jon Love; Sigurdur Yngvi Kristinsson
Veröffentlicht in: Annals of Internal Medicine, Ausgabe Volume 177, Number 4, 2024, ISSN 0003-4819
Herausgeber: American College of Physicians (ACP)
DOI: 10.7326/m23-2540

Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry: Proposal for a bone marrow quality index

Autoren: Jón Þórir Óskarsson,corresponding author1 Sæmundur Rögnvaldsson,1,2 Sigrun Thorsteinsdottir,1,3 Thor Aspelund,4 Steinar Bragi Gunnarsson,1 Guðlaug Katrín Hákonardóttir,1 Guðrún Ásta Sigurðardóttir,1 Ásdís Rósa Þórðardóttir,1 Gauti Kjartan Gíslason,1 Andri
Veröffentlicht in: Blood Cancer Journal, Ausgabe 2023 Dec; 13(1): 177, 2023, ISSN 2044-5385
Herausgeber: Springer Nature
DOI: 10.1038/s41408-023-00951-2

The consultant's guide to smoldering multiple myeloma

Autoren: Sigrun Thorsteinsdottir, Sigurdur Yngvi Kristinsson
Veröffentlicht in: Hematology, ASH Education Program, Ausgabe 2022 Dec 9; 2022 (1):551-559, 2022, ISSN 1520-4391
Herausgeber: American Society of Hematology (ASH)
DOI: 10.1182/hematology.2022000355

Screening in Multiple Myeloma and Its Precursors: Are We There Yet?

Autoren: Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Sigurður Yngvi Kristinsson
Veröffentlicht in: Clinical Chemistry, Ausgabe Volume 70, Ausgabe 1, 2024, ISSN 0009-9147
Herausgeber: Oxford Academic
DOI: 10.1093/clinchem/hvad148

Prevalence of smoldering multiple myeloma based on nationwide screening

Autoren: Sigrun Thorsteinsdottir, Gauti K Gislason, Thor Aspelun, Saemundur Rognvaldsson, Jon Thorir Oskarsson, Sigurdur Yngvi Kristinsson
Veröffentlicht in: Nature Medicine, Ausgabe 2023 Feb; 29(2): 467-472, 2023, ISSN 1078-8956
Herausgeber: Springer Nature
DOI: 10.1038/s41591-022-02183-6

Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study

Autoren: Aðalbjörg Ýr Sigurbergsdóttir, 1 Sæmundur Rögnvaldsson, 1 , 2 Sigrún Thorsteinsdóttir, 1 , 3 Ingigerður Sverrisdóttir, 1 , 4 Guðrún Ásta Sigurðardóttir, 1 Brynjar Viðarsson, 2 Páll Torfi Önundarson, 1 , 2 Bjarni A. Agnarsson, 2 Margrét Sigurðardóttir, 2 I
Veröffentlicht in: Haematologica, Ausgabe 2023 Dec 1; 108 (12): 3392-3398, 2023, ISSN 0390-6078
Herausgeber: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.283191

Conference proceedings (16)

Prevalence of MGUS Is High in the Istopmm Study but the Prevalence of IgA MGUS Does Not Increase with Age in the Way Other Immunoglobulin Subtypes Do

Autoren: Thorvardur Jon Love, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Thor Aspelund, Elin Ruth Reed, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Isleifur Olafss
Veröffentlicht in: Blood, Ausgabe Volum 140, Ausgabe Supplement 1: 256-258, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-163169

P900: INVOLVED/UNINVOLVED SERUM FREE LIGHT CHAIN RATIO IS A STRONGER PREDICTOR OF DIAGNOSTIC/RISK FACTORS IN LIGHT CHAIN COMPARED TO HEAVY CHAIN MONOCLONAL GAMMOPATHIES

Autoren: Jon Thorir Oskarsson,1 Sigrún Þorsteinsdóttir,1 Sæmundur Rögnvaldsson,1 Guðrún Ásta Sigurðardóttir,1 Ásdís Rósa Þórðardóttir,1 Gauti Kjartan Gíslason,1 Andri Ólafsson,1 Jón Kristinn Sigurðsson,1 Elías Eyþórsson,3 Ásbjörn Jónsson,4 Brynjar Viðarsson,3 Páll
Veröffentlicht in: HemaSphere, Ausgabe 7 (supple): e15034c8, 2023, ISSN 2572-9241
Herausgeber: The European Hematology Association
DOI: 10.1097/01.HS9.0000970504.15034.c8

Autoimmune Diseases Are Not Associated with Monoclonal Gammopathy of Undetermined Significance: Results of the Prospective Population-Based Istopmm Study

Autoren: Ingigerdur S Sverrisdottir, Sigrún Thorsteinsdóttir, Sæmundur Rögnvaldsson, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Önundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ingunn Thorsteinsdottir, Signy Vala Sveinsdottir, Robert Palmason, Ísleifur Ólaf
Veröffentlicht in: Blood, Ausgabe Vol 140, Supplement 1: 10031-10032, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-169393

Predicting an Underlying Clonal Plasma Cell Population in Light-Chain Monoclonal Gammopathy of Undetermined Significance Using Free Light-Chain Ratio

Autoren: Jon Thorir Oskarsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Thorir E. Long, Gudrun Asta Sigurdardottir, Asdis Rosa Thordardottir, Gauti Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Elias Eythorsson, Asbjorn Jonsson, Brynjar Vidarsson, Pall
Veröffentlicht in: Blood, Ausgabe Vol 142 Supplement 1: 530, 2023, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2023-182661

Monoclonal Gammopathy of Undetermined Significance (MGUS) with Multiple Paraproteins: Results from the Population-Based Istopmm Screening Study

Autoren: Sæmundur Rögnvaldsson, Jon Þórir Oskarsson, Sigrun Thorsteinsdottir, Elin Ruth Reed, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson, Margret Sigurdardottir, Bjarni Agnar Agnarsson, Isleifur Olafsson, Ingunn Thorsteinsdottir, Signy Va
Veröffentlicht in: Blood, Ausgabe Vol 140, Supplement 1: 10024-10026, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-168070

Revised Definition of Free Light Chains in Serum and Light Chain Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Autoren: Thorir Einarsson Long, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Olafur Indridason, Runolfur Palsson, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Ingunn
Veröffentlicht in: Blood, Ausgabe Vol 142 Supplement 1: 535, 2023, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2023-188547

Transient M-Proteins: Epidemiology, Causes, and the Impact of Mass Spectrometry: The Istopmm Study

Autoren: Robert Palmason, Oscar Berlanga, Jon Kristinn Sigurdsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Sara Ekberg, Michael Crowther, Marina Levy, Elin Ruth Reed, Jon Þórir Oskarsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall Torfi Onundarson
Veröffentlicht in: Blood, Ausgabe Blood(2022) 140(Supplement 1):2338-2340, 2022, ISSN 0006-4971
Herausgeber: American Society of Hematology
DOI: 10.1182/blood-2022-164758

Monoclonal Gammopathy of Undetermined Significance and the Risk of Thrombotic Events: Results from Istopmm, a Population-Based Screening Study in Iceland

Autoren: Sæmundur Rögnvaldsson, Alessandro Gasparini, Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Elias Eythorsson, Thorir E. Long, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir,
Veröffentlicht in: Blood, Ausgabe Vol 142, Supplement 1: 216, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2023-186098

Predicting the Need for Upfront Bone Marrow Sampling in Individuals with MGUS: Derivation of a Multivariable Prediction Model Using the Prospective Population-Based Istopmm Cohort

Autoren: Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Elin Ruth Reed, Gudrún Ásta Sigurdardóttir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, Ísleifur Ólafsson, Ingunn Þorsteinsdóttir, Signy Vala Sveinsd
Veröffentlicht in: Blood, Ausgabe Volume 140, Supplement 1: 266-267, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-170166

Detection of abnormal plasma cells by multiparameter flow cytometry in a screened cohort of patients with monoclonal gammopathy of undetermined significance

Autoren: Jón Þórir Óskarsson , Sæmundur Rögnvaldsson , Sigrún Þorsteinsdóttir , Íris Pétursdóttir , Hrafnhildur Una Þórðardóttir , Steinar Bragi Gunnarsson , Guðlaug Katrín Hákonardóttir , Guðrún Ásta Sigurðardóttir , Ásdís Rósa Þórðardóttir , Gauti Kjart
Veröffentlicht in: Clinical Lymphoma Myeloma and Leukemia, Ausgabe Volume 22, Supplement, August 2022, page S22, 2022, ISSN 2152-2650
Herausgeber: Elsevier
DOI: 10.1016/S2152-2650(22)00310-X

Monoclonal Gammopathy of Undetermined Significance and Risk of Chronic Kidney Disease: Results of the Population-Based Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Autoren: Thorir Einarsson Long, Elias Eythorsson, Sæmundur Rögnvaldsson, Olafur Indridason, Runolfur Palsson, Sigrún Thorsteinsdóttir, Ingigerdur S Sverrisdottir, Thor Aspelund, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnarsson, Margrét Sigurdardóttir, In
Veröffentlicht in: Blood, Ausgabe Volume 140, supplement 1: 10108-10109, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-170623

Risk factors of smoldering multiple myeloma: Results from the screened iStopMM study

Autoren: Sigrun Thorsteinsdottir, Ingigerdur Sverrisdottir, Saemundur Rognvaldsson, Sigurdur Yngvi Kristinsson
Veröffentlicht in: Blood, 2023, ISSN 1528-0020
Herausgeber: The American Society of Hematology
DOI: 10.1182/blood-2023-188469

The Early Benefits and Psychological Effects of Screening for Monoclonal Gammopathy of Undetermined Significance: Results of the Istopmm Study

Autoren: Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Jon Oskarsson, Elias Eythorsson, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Andri Steinthor Bjorn
Veröffentlicht in: Blood, Ausgabe Vol 142 Supplement 1: 214, 2023, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2023-186397

Sars-Cov-2 Infection Does Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study

Autoren: Robert Palmason, Sara Ekberg, Elias Eythorsson, Sæmundur Rögnvaldsson, Sigrun Thorsteinsdottir, Michael Crowther, Elin Ruth Reed, Jon Oskarsson, Gudrun Asta Sigurdardottir, Thor Aspelund, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Si
Veröffentlicht in: Blood, Ausgabe Vol 142 Supplement 1: 4766, 2023, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2023-173078

Circulating Tumor Plasma Cells in the Screened Istopmm Smoldering Multiple Myeloma Cohort

Autoren: Sigrún Thorsteinsdóttir, Jon Þórir Oskarsson, Sæmundur Rögnvaldsson, Gauti Gíslason, Thor Aspelund, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Brynjar Vidarsson, Páll Torfi Onundarson, Bjarni Agnar Agnarsson, Margrét Sigurdardóttir, Ingunn Thor
Veröffentlicht in: Blood, Ausgabe Vol 140, Supplement 1: 9923-9924, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-168690

Determining Hemodilution in Diagnostic Bone Marrow Samples in Multiple Myeloma and Its Precursors By Next-Generation Flow Cytometry: Data from the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) Study

Autoren: Jón Þórir Óskarsson, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Hrafnhildur Una þórðardóttir, Gudlaug Katrin Hakonardottir, Steinar Bragi Gunnarsson, Gudrún Ásta Sigurdardóttir, Ásdis Rósa Thórdardottir, Gauti Gíslason, Andri Olafsson, Jon Kristinn S
Veröffentlicht in: Blood, Ausgabe Vol 140 Supplement 1: 7166-7167, 2022, ISSN 0006-4971
Herausgeber: ASH Publications
DOI: 10.1182/blood-2022-168741