The role of mitochondrial proteins in cell fitness
Although mitochondria – the powerhouses of the cell – contain a separate mitochondrial genome, most mitochondrial proteins are encoded by nuclear genes. They are thus synthesised in the cytosol as precursor proteins and subsequently imported to mitochondria. The working hypothesis of the EU-funded MitoCyto project is that during their cytosolic residence, mitochondrial precursor proteins may affect cellular homeostasis. Considering that aberrant accumulation of cytosolic proteins is a hallmark of ageing and neurodegeneration, researchers aim to elucidate the interactions of mitochondrial cytosolic precursors and how they may affect eukaryotic cell fitness. MitoCyto will offer fundamental insight into cell biology; moreover, project results will also have relevance for conditions other than ageing.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme